دوره 9، شماره 2 - ( 1403 )
دوره 9 شماره 2 صفحات 85-67 |
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Rasoul Panah S, Kolahdoozha A, Mohammadi H. Immunological Diagnostics for Infertility: Cellular, Molecular, and Genetic Comprehensive Review. SJMR 2024; 9 (2) : 3
URL: http://saremjrm.com/article-1-332-fa.html
URL: http://saremjrm.com/article-1-332-fa.html
رسول پناه سارا، کلاهدوزها علی، محمدی حامد. تشخیص ایمونولوژیک ناباروری: بررسی جامع سلولی، مولکولی و ژنتیکی. مجله تحقيقات پزشكي صارم. 1403; 9 (2) :67-85
سارا رسول پناه1 
، علی کلاهدوزها1 ، حامد محمدی*1
، علی کلاهدوزها1 ، حامد محمدی*1
1- مرکز تحقیقات بیماری‌های غیرواگیر، دانشگاه علوم پزشکی البرز، کرج، ایران
چکیده: (1210 مشاهده)
بارداری مشتمل بر وضعیت ایمنی منحصر به فردی است که طی آن زنان باردار مکانیسم های تحمل را برای جلوگیری از پس زدن جنین ایجاد می کنند. مکانیسم‌های مختلفی سیستم ایمنی مادر را تعدیل می‌کنند تا از این پس زدن جلوگیری کنند. علی‌رغم این مکانیسم‌ها، ناباروری تقریباً 12-8 درصد از زوج‌های در سن باروری را تحت تأثیر قرار می‌دهد، به‌ویژه آنهایی که شکست مکرر لانه‌گزینی و سقط مکرر بارداری را تجربه می‌کنند. تکنیک های کمک باروری در دهه های اخیر به طور قابل توجهی پیشرفت کرده اند، اما میزان موفقیت نسبتاً پایین باقی مانده است. پروفایل ایمنی آندومتر در درک ناباروری بسیار مهم است و یک ریزمحیط متمایز در دوران بارداری را تشکیل می دهد. در نتیجه، تحقیقات بر روی تجزیه و تحلیل نشانگرهای زیستی خاص، سایتوکین ها و شناسایی اختلالات سیستم ایمنی در این زمینه متمرکز شده است. هدف این رویکرد ارائه بینش برای توسعه درمان های شخصی است. این مطالعه با هدف فراهم آوردن آگاهی در زمینه نشانگرهای ایمنی سلولی، نشانگرهای مولکولی/ژنتیکی در مطالعات آندومتر و اتوآنتی بادی‌های دخیل در ناباروری صورت پذیرفته است.
شماره‌ی مقاله: 3
نوع مقاله: مروری تحلیلی |
موضوع مقاله:
ناباروری
دریافت: 1403/5/10 | پذیرش: 1403/5/25 | انتشار: 1403/9/21
دریافت: 1403/5/10 | پذیرش: 1403/5/25 | انتشار: 1403/9/21
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