Volume 11, Issue 3 (2026)
SJMR 2026, 11(3): 131-137 |
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Giti S, Sanaye Naderi M, Mohammadian H. Successful Management of Two Cases of Nephrotic Syndrome During Pregnancy: The Case Report. SJMR 2026; 11 (3) : 5
URL: http://saremjrm.com/article-1-408-en.html
URL: http://saremjrm.com/article-1-408-en.html
1- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran.
2- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
2- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
Abstract: (15 Views)
Introduction: Nephrotic syndrome during pregnancy is an important clinical condition that may be associated with maternal and fetal complications and requires careful maternal and fetal monitoring and follow-up. The management of these patients, particularly in cases complicated by pregnancy-related conditions, can be challenging in terms of diagnosis, maternal and fetal surveillance, and determining the appropriate timing of pregnancy termination. Given the importance of appropriate management in these patients, reporting the experience of specialized centers may contribute to a better understanding of the course of care and pregnancy outcomes in women with nephrotic syndrome. The aim of this case report was to describe the experience of Sarem Women’s Hospital in Tehran in managing two pregnancies complicated by nephrotic syndrome and to assess the maternal and neonatal outcomes of these cases.
Case Presentation: In this report, two cases of pregnancy complicated by nephrotic syndrome are presented. The first case was a 34-year-old woman who was admitted at 36 weeks and 2 days of gestation for termination of pregnancy by cesarean section due to intrauterine growth restriction (IUGR) and abnormal fetal Doppler findings. Her pregnancy had been reported as normal up to that time, and prenatal screening tests and fetal echocardiography were normal. A male infant was delivered with Apgar scores of 10 and 9 and a reported birth weight of 2,410 gr. The second case was a 30-year-old woman with a history of preeclampsia in a previous pregnancy and a history of follow-up by a nephrologist, who received treatment and care during pregnancy. She was admitted at 37 weeks of gestation for cesarean section, and a female infant was delivered with a birth weight of 2,510 gr and Apgar scores of 10 and 9. The general condition of both neonates after birth was reported to be favorable.
Conclusion: These two cases demonstrate that pregnancy in patients with nephrotic syndrome may require close monitoring and collaboration between obstetricians and nephrologists. Monitoring maternal and fetal status and determining the appropriate timing and mode of pregnancy termination according to the clinical conditions of the mother and fetus are important components of the management of these patients. Given the limited information available in the medical records, further evaluation of clinical and laboratory parameters and longer-term follow-up are necessary for a more comprehensive assessment of disease progression and the effectiveness of therapeutic interventions.
Case Presentation: In this report, two cases of pregnancy complicated by nephrotic syndrome are presented. The first case was a 34-year-old woman who was admitted at 36 weeks and 2 days of gestation for termination of pregnancy by cesarean section due to intrauterine growth restriction (IUGR) and abnormal fetal Doppler findings. Her pregnancy had been reported as normal up to that time, and prenatal screening tests and fetal echocardiography were normal. A male infant was delivered with Apgar scores of 10 and 9 and a reported birth weight of 2,410 gr. The second case was a 30-year-old woman with a history of preeclampsia in a previous pregnancy and a history of follow-up by a nephrologist, who received treatment and care during pregnancy. She was admitted at 37 weeks of gestation for cesarean section, and a female infant was delivered with a birth weight of 2,510 gr and Apgar scores of 10 and 9. The general condition of both neonates after birth was reported to be favorable.
Conclusion: These two cases demonstrate that pregnancy in patients with nephrotic syndrome may require close monitoring and collaboration between obstetricians and nephrologists. Monitoring maternal and fetal status and determining the appropriate timing and mode of pregnancy termination according to the clinical conditions of the mother and fetus are important components of the management of these patients. Given the limited information available in the medical records, further evaluation of clinical and laboratory parameters and longer-term follow-up are necessary for a more comprehensive assessment of disease progression and the effectiveness of therapeutic interventions.
Article number: 5
Keywords: Nephrotic syndrome, Pregnancy, Kidney Disease, Cesarean Section, Intrauterine Growth Restriction, Case Report.
Article Type: Case Report |
Subject:
Pregnancy Care
Received: 2026/09/17 | Accepted: 2026/09/21 | Published: 2026/10/22
Received: 2026/09/17 | Accepted: 2026/09/21 | Published: 2026/10/22
References
1. 1. Piscitani L, Sipari P, Di Pietro LO, Bussolaro S, Guido M, Fantasia I, Kidney and Pregnancy: A Comprehensive Review. Clin Pract, 2025. 15. (10). [DOI:10.3390/clinpract15100189] [PMID] [PMCID]
2. Waleed SM, Salih A-HM, Hussain SS, Physiological impact of pregnancy on renal function; a prospective cohort study. Journal of Nephropathology, 2026. 15(4): e28708-e28708.
3. Maressa V, Longhitano E, Casuscelli C, Di Carlo S, Peritore L, Santoro D, Pregnancy in Glomerular Disease: From Risk Identification to Counseling and Management. J Clin Med, 2024. 13.(6) [DOI:10.3390/jcm13061693] [PMID] [PMCID]
4. 4. Christopher M, Jacob A, Newbigging N, Lenin A, Sathyendra S, Abraham A, et al., Proteinuria Unrelated to Pregnancy-Induced Hypertension: More than 1200mg in 24 hours is Associated with Renal Disease and Adverse Pregnancy Outcomes. Current Medical Issues, 2026. 24: 160-165. [DOI:10.4103/cmi.cmi_138_25]
5. Marques LPJ, Salla LM, Rioja LDS, Rocco R, Madeira EPQ, Vieira L, The effects of pregnancy on the progression of maternal glomerular disease. J Bras Nefrol, 2025. 47(4): e20240205. [DOI:10.1590/2175-8239-jbn-2024-0205pt] [PMCID]
6. Verma P, Patil P, Nephrotic Syndrome: A Review. Cureus, 2024. [DOI:10.7759/cureus.53923]
7. Berke I, Bruchfeld A, Frangou E, Moran SM, Quintana LF, Stevens KI, et al., Ten tips for the diagnosis and management of nephrotic syndrome. Clinical Kidney Journal, 2026. 19.(9) [DOI:10.1093/ckj/sfag268] [PMID] [PMCID]
8. Meena P, Jesudason S, Popa CA, Rao NS, Priyamvada PS, Approach to Glomerular Disease in Pregnancy. Indian J Nephrol, 2024. 34(6): 561-572. [DOI:10.25259/IJN_26_2024] [PMID] [PMCID]
9. Smyth A, Radovic M, Garovic VD, Women, kidney disease, and pregnancy. Adv Chronic Kidney Dis, 2013. 20(5): 402-10. [DOI:10.1053/j.ackd.2013.06.004] [PMID] [PMCID]
10. Li D, Zhang M, Xu S, Bian Z, Huang X, Hu G, et al., A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia. BMC Pregnancy Childbirth, 2023. 23(1): 773. [DOI:10.1186/s12884-023-06073-8] [PMID]
11. Boza B, Ersan F, Alpay V, Erenel H, The Prognostic Significance of Proteinuria Severity in Pregnancy: A Retrospective Cohort Study of Maternal and Neonatal Outcomes. Journal of Clinical Medicine, 2026. 15(1): 345. [DOI:10.3390/jcm15010345] [PMID] [PMCID]
12. De Castro I, Easterling TR, Bansal N, Jefferson JA, Nephrotic syndrome in pregnancy poses risks with both maternal and fetal complications. Kidney international, 2017. 91(6): 1464-1472. [DOI:10.1016/j.kint.2016.12.019] [PMID]
13. Verma PR, Patil P, Nephrotic Syndrome: A Review. Cureus, 2024. 16(2): e53923. [DOI:10.7759/cureus.53923]
14. Boza B, Ersan F, Alpay V, Erenel H, The Prognostic Significance of Proteinuria Severity in Pregnancy: A Retrospective Cohort Study of Maternal and Neonatal Outcomes. J Clin Med, 2026. 15.(1) [DOI:10.3390/jcm15010345] [PMID] [PMCID]
15. Thadhani RI, Maynard SE, Proteinuria in pregnancy: Evaluation and management. Monografía internet). Glassock RJ: UpToDate, 2015: 1-150.
16. Chang KJ, Seow KM, Chen KH, Preeclampsia: Recent Advances in Predicting, Preventing, and Managing the Maternal and Fetal Life-Threatening Condition. Int J Environ Res Public Health, 2023. 20.(4) [DOI:10.3390/ijerph20042994] [PMID] [PMCID]
17. Rasmussen S, Irgens L, Fetal Growth and Body Proportion in Preeclampsia. Obstetrics and gynecology, 2003. 101: 575-83. [DOI:10.1097/00006250-200303000-00026] [PMID]
18. Fadailu ME, Saad MA, Alghilan NA, Ali M, Management Challenges of a Pregnant Woman With Undiagnosed Nephrotic Syndrome: Experience From Saudi Arabia. Cureus, 2025. 17(8): e89347. [DOI:10.7759/cureus.89347] [PMID] [PMCID]
19. Piccoli GB, Zakharova E, Attini R, Ibarra Hernandez M, Orozco Guillien A, Alrukhaimi M, et al., Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases. J Clin Med, 2018. 7.(11) [DOI:10.3390/jcm7110415] [PMID] [PMCID]
20. Blom K, Odutayo A, Bramham K, Hladunewich MA, Pregnancy and Glomerular Disease: A Systematic Review of the Literature with Management Guidelines. Clin J Am Soc Nephrol, 2017. 12(11): 1862-1872. [DOI:10.2215/CJN.00130117] [PMID] [PMCID]
21. Marinaki S, Tsiakas S, Skalioti C, Kapsia E, Lionaki S, Vallianou K, et al., Pregnancy in Women With Preexisting Glomerular Diseases: A Single-Center Experience. Front Med (Lausanne), 2022. 9: 801144. [DOI:10.3389/fmed.2022.801144] [PMID] [PMCID]
22. Sebestyen A, Varbiro S, Sara L, Deak G, Kerkovits L, Szabo I, et al., Successful management of pregnancy with nephrotic syndrome due to preexisting membranous glomerulonep
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