Volume 10, Issue 4 (2025)
SJMR 2025, 10(4): 203-208 |
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Arab M, Pirastehfar Z, Nouri N, Saket S, Faghih N, Ghavami B. Intrauterine Growth Restriction and other pregnancy complications following covid-19 infection. SJMR 2025; 10 (4) : 6
URL: http://saremjrm.com/article-1-376-en.html
URL: http://saremjrm.com/article-1-376-en.html
Maliheh Arab *1 
, Zanbagh Pirastehfar2 , Nasim Nouri3 , Sadaf Saket4 , Nafiseh Faghih5 , Behnaz Ghavami6
, Zanbagh Pirastehfar2 , Nasim Nouri3 , Sadaf Saket4 , Nafiseh Faghih5 , Behnaz Ghavami6
1- Professor of Gyneco- oncology. Shahid Beheshti University of Medical Sciences and Health Services. Tehran. Iran , drmarab@sbmu.ac.ir
2- Department of Obstetrics and Gynecology. School of Medicine. Imam Khomeini Hospital. Mazandaran University of Medical Sciences. Sari. Iran.
3- Medical Doctor.School of Medicine. Shahid Beheshti University of Medical Sciences and Health Services. Tehran. Iran
4- . Shahid Beheshti University of Medical Scienceand Health Services.Taleghani hospital. Tehran. Iran
5- Assistant professor of Gyneco-oncology. Shahid Beheshti University of Medical Sciences and Health Services. Tehran. Iran
6- Obstetrician & Gynecologist. Fellowship of laparoscopy. Tehran. Iran.
2- Department of Obstetrics and Gynecology. School of Medicine. Imam Khomeini Hospital. Mazandaran University of Medical Sciences. Sari. Iran.
3- Medical Doctor.School of Medicine. Shahid Beheshti University of Medical Sciences and Health Services. Tehran. Iran
4- . Shahid Beheshti University of Medical Scienceand Health Services.Taleghani hospital. Tehran. Iran
5- Assistant professor of Gyneco-oncology. Shahid Beheshti University of Medical Sciences and Health Services. Tehran. Iran
6- Obstetrician & Gynecologist. Fellowship of laparoscopy. Tehran. Iran.
Abstract: (20 Views)
Background: The WHO, reported world widespread coronavirus disease (COVID-19) as an international public health emergency. Pregnancy is associated with immunological changes that may make women susceptible to COVID-19. The present study was conducted to clarify the impacts of the pandemic on intrauterine growth restriction (IUGR) and other pregnancy complications.
Material & methods: In a historical cohort study, COVID-19-positive cases who were hospitalized and a subgroup of Intensive Care Unit (ICU)-admitted (severe) cases were compared with those who had no history of COVID-19 infection, regarding IUGR and other complications of pregnancy.
Results: Among 1010 pregnant women enrolled in the study, 43 (4.3%) had a history of hospitalization due to COVID-19 (including 28 ICU-admitted severe cases) through pregnancy and the other 967 cases who had no history of infection were compared. In comparing COVID-19 with non-COVID-19 groups, IUGR, and preterm labor were more frequent in the COVID-19 group (16.3% versus 6.9%) and (51.2% versus 19.9%), respectively. Also, the cesarean section rate was higher (75% versus 55.3%) and the low APGAR score was more frequent (16.3% versus 3.3-3.7%)
Conclusion: Complications of COVID-19 infection in pregnancy such as IUGR, preterm labor, higher rate of cesarean section, and low APGAR score might make pregnant women more vulnerable to the COVID-19 pandemic and probable future versions of viral pandemics.
Material & methods: In a historical cohort study, COVID-19-positive cases who were hospitalized and a subgroup of Intensive Care Unit (ICU)-admitted (severe) cases were compared with those who had no history of COVID-19 infection, regarding IUGR and other complications of pregnancy.
Results: Among 1010 pregnant women enrolled in the study, 43 (4.3%) had a history of hospitalization due to COVID-19 (including 28 ICU-admitted severe cases) through pregnancy and the other 967 cases who had no history of infection were compared. In comparing COVID-19 with non-COVID-19 groups, IUGR, and preterm labor were more frequent in the COVID-19 group (16.3% versus 6.9%) and (51.2% versus 19.9%), respectively. Also, the cesarean section rate was higher (75% versus 55.3%) and the low APGAR score was more frequent (16.3% versus 3.3-3.7%)
Conclusion: Complications of COVID-19 infection in pregnancy such as IUGR, preterm labor, higher rate of cesarean section, and low APGAR score might make pregnant women more vulnerable to the COVID-19 pandemic and probable future versions of viral pandemics.
Article number: 6
Article Type: Original Research |
Subject:
Women Diseases
Received: 2025/10/8 | Accepted: 2026/02/14 | Published: 2026/02/28
Received: 2025/10/8 | Accepted: 2026/02/14 | Published: 2026/02/28
References
1. Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306. [DOI:10.1111/aji.13306] [PMID] []
2. Khan M, Adil SF, Alkhathlan HZ, Tahir MN, Saif S, Khan M, et al. COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules. 2020;26(1). [DOI:10.3390/molecules26010039] [PMID] []
3. Mirbeyk M, Saghazadeh A, Rezaei N. A systematic review of pregnant women with COVID-19 and their neonates. Arch Gynecol Obstet. 2021;304(1):5-38. [DOI:10.1007/s00404-021-06049-z] [PMID] []
4. Zimmermann P, Curtis N. COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features. Pediatr Infect Dis J. 2020;39(6):469-77. [DOI:10.1097/INF.0000000000002700] [PMID] []
5. Sahu S, Laishram G, Rannaware A, Choudhari SG. Impact of COVID-19 on Pregnancy and Maternal-Neonatal Outcomes: A Narrative Review. Cureus. 2022;14(11):e31397. [DOI:10.7759/cureus.31397]
6. Di Mascio D, Khalil A, Saccone G, Rizzo G, Buca D, Liberati M, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107. [DOI:10.1016/j.ajogmf.2020.100107] [PMID] []
7. Saleh Gargari S, Rahmati N, Fateh R, Khandani A, Nikfar S, Ghafouri-Fard S. Investigation of maternal and perinatal outcome in a population of Iranian pregnant women infected with COVID-19. Sci Rep. 2022;12(1):9815. [DOI:10.1038/s41598-022-14112-1] [PMID] []
8. Bahrami R, Schwartz DA, Karimi-Zarchi M, Javaheri A, Dastgheib SA, Ferdosian F, et al. Meta-analysis of the frequency of intrauterine growth restriction and preterm premature rupture of the membranes in pregnant women with COVID-19. Turk J Obstet Gynecol. 2021;18(3):236-44. [DOI:10.4274/tjod.galenos.2021.74829] [PMID] []
9. Shree P, Mittal N, Vishwakarma S, Verma V, Pandey V, Thadani E. Maternal and Perinatal Outcomes of COVID-19-Positive Pregnant Women. Cureus. 2022;14(6):e26411. [DOI:10.7759/cureus.26411]
10. Darendeliler F. IUGR: Genetic influences, metabolic problems, environmental associations/triggers, current and future management. Best Pract Res Clin Endocrinol Metab. 2019;33(3):101260. [DOI:10.1016/j.beem.2019.01.001] [PMID]
11. Cavalcante MB, Cavalcante C, Sarno M, Barini R, Kwak-Kim J. Maternal immune responses and obstetrical outcomes of pregnant women with COVID-19 and possible health risks of offspring. J Reprod Immunol. 2021;143:103250. [DOI:10.1016/j.jri.2020.103250] [PMID] []
12. Silasi M, Cardenas I, Kwon JY, Racicot K, Aldo P, Mor G. Viral infections during pregnancy. Am J Reprod Immunol. 2015;73(3):199-213. [DOI:10.1111/aji.12355] [PMID] []
13. Pschirrer ER, Monga M. Risk factors for preterm labor. Clin Obstet Gynecol. 2000;43(4):727-34. [DOI:10.1097/00003081-200012000-00003] [PMID]
14. Male V. SARS-CoV-2 infection and COVID-19 vaccination in pregnancy. Nat Rev Immunol. 2022;22(5):277-82. [DOI:10.1038/s41577-022-00703-6] [PMID] []
15. Sandall J, Tribe RM, Avery L, Mola G, Visser GH, Homer CS, et al. Short-term and long-term effects of 1. Prochaska E, Jang M, Burd I. COVID-19 in pregnancy: Placental and neonatal involvement. Am J Reprod Immunol. 2020;84(5):e13306. [DOI:10.1111/aji.13306] [PMID] []
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