Volume 10, Issue 3 (2025)
SJMR 2025, 10(3): 125-130 |
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Nateghi M R, Alijani L, Sanaye Naderi M, Mohammadian H. Primary Retroperitoneal Mucinous Cystadenocarcinoma in Pregnancy (PRMC): A Very Rare Case Report, Diagnostic and Therapeutic Challenges. SJMR 2025; 10 (3) : 3
URL: http://saremjrm.com/article-1-374-en.html
URL: http://saremjrm.com/article-1-374-en.html
1- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences, Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
2- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences, Tehran, Iran.
Abstract: (15 Views)
Introduction: Primary retroperitoneal mucinous cystadenocarcinoma (PRMC) is an exceedingly rare tumor, and its diagnosis during pregnancy poses significant challenges. The scarcity of clinical evidence and the complexity of differential diagnoses further complicate management. The aim of this report was to present and analyze a rare case of PRMC in pregnancy and to review the associated diagnostic and therapeutic considerations.
Case Presentation: A 46-year-old multiparous woman with a history of multiple pregnancies and repeated IVF cycles (the most recent with donor oocytes) was found to have a right adnexal cyst measuring 8 cm on routine ultrasound at 28 weeks of gestation. Tumor markers were within normal ranges, and the cyst showed no significant growth until 33 weeks. Based on a multidisciplinary decision and to ensure fetal lung maturity, the patient received betamethasone and magnesium sulfate. At 34 weeks, a cesarean section was performed via a midline incision, resulting in the delivery of a healthy infant with Apgar scores of 9 and 8. Intraoperatively, adnexa appeared normal; however, a retroperitoneal mass measuring approximately 9×8 cm was unexpectedly discovered and completely excised. Final histopathology confirmed PRMC. Postoperative follow-up, including colonoscopy, upper endoscopy, abdominopelvic CT scan, ultrasonography, and mammography, revealed no pathological findings.
Conclusion: This case demonstrates that PRMC may present during pregnancy with minimal clinical manifestations and normal tumor markers. Timely diagnosis, multidisciplinary decision-making, and appropriate timing of surgical intervention are critical for successful management. Comprehensive postoperative follow-up is essential to exclude secondary origins and to monitor for possible recurrence.
Case Presentation: A 46-year-old multiparous woman with a history of multiple pregnancies and repeated IVF cycles (the most recent with donor oocytes) was found to have a right adnexal cyst measuring 8 cm on routine ultrasound at 28 weeks of gestation. Tumor markers were within normal ranges, and the cyst showed no significant growth until 33 weeks. Based on a multidisciplinary decision and to ensure fetal lung maturity, the patient received betamethasone and magnesium sulfate. At 34 weeks, a cesarean section was performed via a midline incision, resulting in the delivery of a healthy infant with Apgar scores of 9 and 8. Intraoperatively, adnexa appeared normal; however, a retroperitoneal mass measuring approximately 9×8 cm was unexpectedly discovered and completely excised. Final histopathology confirmed PRMC. Postoperative follow-up, including colonoscopy, upper endoscopy, abdominopelvic CT scan, ultrasonography, and mammography, revealed no pathological findings.
Conclusion: This case demonstrates that PRMC may present during pregnancy with minimal clinical manifestations and normal tumor markers. Timely diagnosis, multidisciplinary decision-making, and appropriate timing of surgical intervention are critical for successful management. Comprehensive postoperative follow-up is essential to exclude secondary origins and to monitor for possible recurrence.
Article number: 3
Keywords: Primary Retroperitoneal Mucinous Cystadenocarcinoma (PRMC), Pregnancy, Adnexal Cyst, Case Report.
Article Type: Case Report |
Subject:
Pregnancy Care
Received: 2025/09/22 | Accepted: 2025/09/25 | Published: 2025/09/27
Received: 2025/09/22 | Accepted: 2025/09/25 | Published: 2025/09/27
References
1. 1 Chaves, M. M., Castro, R., Mota-Vieira, L. & Carneiro, V. A rare case of a primary retroperitoneal mucinous cystic tumour with borderline malignancy and literature review. BMJ case reports 12, doi:10.1136/bcr-2019-230708 (2019). [DOI:10.1136/bcr-2019-230708] [PMID] []
2. 2 Tomioka, M. et al. Primary Retroperitoneal Mucinous Cystadenocarcinoma in a Male Patient: A Case Report. Current Oncology 32, 500 (2025). [DOI:10.3390/curroncol32090500] [PMID]
3. 3 Myriokefalitaki, E. et al. Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis. Archives of gynecology and obstetrics 293, 709-720 (2016). [DOI:10.1007/s00404-015-3975-8] [PMID]
4. 4 Pesapane, F., Renterghem, S., Patella, F., De Visschere, P. & Villeirs, G. A Case Report and a Literature Review of Primary Retroperitoneal Mucinous Cystadenoma: The Importance of Imaging in Diagnosis and Management. Future Oncology 14, doi:10.2217/fon-2017-0649 (2018). [DOI:10.2217/fon-2017-0649] [PMID]
5. 5 Myriokefalitaki, E. et al. Primary retroperitoneal mucinous cystadenocarcinoma (PRMCa): a systematic review of the literature and meta-analysis. Archives of gynecology and obstetrics 293, doi:10.1007/s00404-015-3975-8 (2016). [DOI:10.1007/s00404-015-3975-8] [PMID]
6. 6 Joldoshova, A., Belousova, T., Cai, Z. & Billah, S. Primary retroperitoneal mucinous cystic neoplasm leading to multifocal invasive adenocarcinoma of the small and large intestine. Human Pathology: Case Reports 22, 200419, doi:
https://doi.org/10.1016/j.ehpc.2020.200419 [DOI:10.1016/j.ehpc.2020.200419 (2020).]
7. 7 Lee, S. Y. & Han, W. C. Primary Retroperitoneal Mucinous Cystadenoma. Annals of coloproctology 32, 33-37, doi:10.3393/ac.2016.32.1.33 (2016). [DOI:10.3393/ac.2016.32.1.33] [PMID] []
8. 8 Sourial, S., Tempest, N. & Hapangama, D. K. Theories on the pathogenesis of endometriosis. International journal of reproductive medicine 2014, 179515, doi:10.1155/2014/179515 (2014). [DOI:10.1155/2014/179515] [PMID] []
9. 9 Lee, S. A. et al. Primary retroperitoneal mucinous cystadenocarcinoma: a case report and review of the literature. The Korean journal of internal medicine 22, 287-291, doi:10.3904/kjim.2007.22.4.287 (2007). [DOI:10.3904/kjim.2007.22.4.287] [PMID] []
10. 10 Leponce, S., Buxant, F. & Noël, J. C. Primary retroperitoneal mucinous carcinoma with BRAF, KIT, NF2, and AR mutations: A case report and review of the literature. Case reports in women's health 45, e00681, doi:10.1016/j.crwh.2025.e00681 (2025). [DOI:10.1016/j.crwh.2025.e00681] [PMID] []
11. 11 de León, D. C. et al. Primary retroperitoneal mucinous cystadenocarcinoma: report of two cases. World journal of surgical oncology 5, 5, doi:10.1186/1477-7819-5-5 (2007). [DOI:10.1186/1477-7819-5-5] [PMID] []
12. 12 Lee, J. et al. MR Imaging of Primary Retroperitoneal Mucinous Cystadenocarcinoma in Pregnant Woman. J Korean Soc Magn Reson Med 17, 243-248 (2013). [DOI:10.13104/jksmrm.2013.17.3.243]
13. 13 Linter-Kapišinská, M., Majernik, J., Ryška, A. & Ninger, V. Primary retroperitoneal mucinous cystadenocarcinoma in pregnancy - case report. Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 100, 357-360, doi:10.33699/pis.2021.100.7.357-360 (2021). [DOI:10.33699/PIS.2021.100.7.357-360]
14. 14 Lee, S. E., Oh, H. C., Park, Y. G., Choi, Y. S. & Kim, M. K. Laparoscopic excision of primary retroperitoneal mucinous cystadenoma and malignant predicting factors derived from literature review. International journal of surgery case reports 9, 130-133, doi:10.1016/j.ijscr.2015.02.050 (2015). [DOI:10.1016/j.ijscr.2015.02.050] [PMID] []
15. 15 Mudhher, R. et al. Literature review and robotic management of a rare case of primary retroperitoneal mucinous cystadenoma. Radiology Case Reports 19, 5798-5803, doi:
https://doi.org/10.1016/j.radcr.2024.08.057 [DOI:10.1016/j.radcr.2024.08.057 (2024).] [PMID] []
16. 16 Mori, A. et al. A Giant Primary Retroperitoneal Serous Cystadenoma: Case Report and Review of Retroperitoneal Cysts. Surgery journal (New York, N.Y.) 3, e32-e37, doi:10.1055/s-0037-1599820 (2017). [DOI:10.1055/s-0037-1599820] [PMID] []
17. 17 Tahmasebi, F., Morje, M., Jamall, H., Polson, A. & Deo, N. Primary retroperitoneal mucinous tumours diagnosed in pregnancy: a case report and literature review. International Journal of Women's Health, 649-653 (2019). [DOI:10.2147/IJWH.S176219] [PMID] []
18. 18 Hanhan, H. M. et al. Primary retroperitoneal mucinous cystadenocarcinoma during pregnancy. Journal of Obstetrics and Gynaecology 34, 535-538, doi:10.3109/01443615.2014.910501 (2014). [DOI:10.3109/01443615.2014.910501] [PMID]
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