Volume 9, Issue 3 (2024)
SJMR 2024, 9(3): 145-163 |
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Yazdi F, Salajegheh P, Salajegheh A, Yazdi yahyaabadi F. Prevalence and Associated Factors of Cervical Spine Instability in Patients with Rheumatoid Arthritis: A Systematic Review and
Meta-Analysis. SJMR 2024; 9 (3) : 3
URL: http://saremjrm.com/article-1-334-en.html
URL: http://saremjrm.com/article-1-334-en.html
1- Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran , Drfarzaneh.yazdi@gmail.com
2- Department of Pediatrics Hematology and Oncology, Endocrinology and Metabolism Research Center, Kerman University of Medical Science, Kerman, Iran
3- Department of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pediatrics, Kerman University of Medical Sciences, Kerman, IranUniversity
2- Department of Pediatrics Hematology and Oncology, Endocrinology and Metabolism Research Center, Kerman University of Medical Science, Kerman, Iran
3- Department of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pediatrics, Kerman University of Medical Sciences, Kerman, IranUniversity
Abstract: (365 Views)
Objective: The aim of this study was to analyze factors associated with cervical spine instability (CSI) in patients with rheumatoid arthritis (RA) through a systematic review and meta-analysis.
Methods: Relevant articles on cervical spine instability in patients with rheumatoid arthritis were collected by searching Embase, PubMed/MEDLINE, Scopus, Web of Science, and Magiran databases up to December 2024. Meta-analysis was conducted using RevMan 5.3 software.
Findings: The cumulative prevalence of CSI in RA patients was 39.08%. The onset of RA symptoms occurred at younger ages in patients with CSI compared to those without CSI. Associated risk factors included a history of joint surgery [OR=1.97, 95% CI: (1.50, 2.59), P<0.00001]; disease duration [MD=4.48, 95% CI: (2.17, 6.80), P=0.0001]; peripheral joint destruction [OR=2.37, 95% CI: (1.96, 2.86), P<0.00001]; erythrocyte sedimentation rate (ESR) [MD=6.34, 95% CI: (3.75, 8.93), P<0.00001]; C-reactive protein (CRP) levels [MD=0.67, 95% CI: (0.25, 1.09), P=0.002]; positive serologic CRP tests [OR=1.79, 95% CI: (1.31, 2.43), P=0.0002]; and treatment with methotrexate [OR=1.30, 95% CI: (1.01, 1.68), P=0.04], corticosteroids [OR=2.26, 95% CI: (1.78, 2.88), P<0.00001], and biologic agents [OR=2.34, 95% CI: (1.58, 3.47), P<0.0001].
Conclusion: The overall prevalence of cervical spine instability in RA patients was 39.08%. Younger age at RA onset, disease duration, history of joint surgery, peripheral joint destruction, ESR, CRP, and treatments with methotrexate, corticosteroids, and biologics were significantly associated with cervical spine instability. These findings provide practical data for the early diagnosis of cervical spine instability in RA patients.
Methods: Relevant articles on cervical spine instability in patients with rheumatoid arthritis were collected by searching Embase, PubMed/MEDLINE, Scopus, Web of Science, and Magiran databases up to December 2024. Meta-analysis was conducted using RevMan 5.3 software.
Findings: The cumulative prevalence of CSI in RA patients was 39.08%. The onset of RA symptoms occurred at younger ages in patients with CSI compared to those without CSI. Associated risk factors included a history of joint surgery [OR=1.97, 95% CI: (1.50, 2.59), P<0.00001]; disease duration [MD=4.48, 95% CI: (2.17, 6.80), P=0.0001]; peripheral joint destruction [OR=2.37, 95% CI: (1.96, 2.86), P<0.00001]; erythrocyte sedimentation rate (ESR) [MD=6.34, 95% CI: (3.75, 8.93), P<0.00001]; C-reactive protein (CRP) levels [MD=0.67, 95% CI: (0.25, 1.09), P=0.002]; positive serologic CRP tests [OR=1.79, 95% CI: (1.31, 2.43), P=0.0002]; and treatment with methotrexate [OR=1.30, 95% CI: (1.01, 1.68), P=0.04], corticosteroids [OR=2.26, 95% CI: (1.78, 2.88), P<0.00001], and biologic agents [OR=2.34, 95% CI: (1.58, 3.47), P<0.0001].
Conclusion: The overall prevalence of cervical spine instability in RA patients was 39.08%. Younger age at RA onset, disease duration, history of joint surgery, peripheral joint destruction, ESR, CRP, and treatments with methotrexate, corticosteroids, and biologics were significantly associated with cervical spine instability. These findings provide practical data for the early diagnosis of cervical spine instability in RA patients.
Article number: 3
Keywords: Rheumatoid Arthritis, Cervical Spine Instability, Atlantoaxial Subluxation, Rheumatoid Factor, Anti-Citrullinated Cyclic Peptide Antibodies, Range of Motion, Corticosteroids.
Article Type: Systematical Review |
Subject:
Health and safety
Received: 2024/11/18 | Accepted: 2024/11/30 | Published: 2025/01/2
Received: 2024/11/18 | Accepted: 2024/11/30 | Published: 2025/01/2
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