Volume 9, Issue 2 (2024)                   SJMR 2024, 9(2): 67-85 | Back to browse issues page

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Rasoul Panah S, Kolahdoozha A, Mohammadi H. Immunological Diagnostics for Infertility: Cellular, Molecular, and Genetic Comprehensive Review. SJMR 2024; 9 (2) : 3
URL: http://saremjrm.com/article-1-332-en.html
Immunological Diagnostics for Infertility: Cellular, Molecular, and Genetic Comprehensive Review
Sara Rasoul Panah1 , Ali Kolahdoozha2 , Hamed Mohammadi *2
1- on-Communicable Diseases, Research Center, Alborz University of Medical Sciences, Karaj, Iran
2- Non-Communicable Diseases, Research Center, Alborz University of Medical Sciences, Karaj, Iran
Abstract:   (911 Views)
Pregnancy represents a unique immunological state where pregnant women develop tolerance mechanisms to avoid fetal rejection. Various mechanisms modulate the maternal immune system to prevent this rejection. Despite these mechanisms, infertility affects approximately 8-12% of reproductive-age couples, particularly those experiencing recurrent implantation failure and recurrent pregnancy loss. Assisted reproductive techniques have significantly advanced in recent decades, yet success rates remain relatively low. Endometrial immune profiling is crucial in understanding infertility and constitutes a distinct microenvironment during pregnancy. Consequently, research has focused on analyzing specific biomarkers, cytokines, and identifying immune system disorders within this context. This approach aims to provide insights for developing personalized treatments. This review examines cellular immune markers, molecular/genetic markers in endometrial studies, and autoantibodies involved in infertility.
Article number: 3
Keywords: Immunological Diagnostics, Infertility, Genetic
Full-Text [PDF 1119 kb]   (632 Downloads)    
Article Type: Analytical Review | Subject: Sterility
Received: 2024/07/31 | Accepted: 2024/08/15 | Published: 2024/12/11
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