Volume 3, Issue 3 (2019)                   SJRM 2019, 3(3): 87-92 | Back to browse issues page

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Mahmoodinia M, Roustaie M. Role of Stem Cells in the Future of Asherman Syndrome Treatment. SJRM. 2019; 3 (3) :87-92
URL: http://saremjrm.com/article-1-129-en.html
1- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran , mahmoodi.scrc@gmail.com
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Abstract:   (446 Views)
Introduction: Endometrium is one of the main parts of the uterus that is complex and dynamic in texture and experiences periods of growth and decline in each periodic cycle. Endometrial diseases, such as Asherman's syndrome cause adhesion to the uterus or cervix and also menstrual problems and pelvic pain. Such diseases can lead to miscarriage or infertility by preventing blastocyst attachment to the uterus or impaired uterine circulation. Recently, cell therapy has been proposed as a novel method to treat tissue damage and fibrosis resulting from destruction. It has been indicated that transplantation of various stem cells from bone marrow or adipose tissue to endometrium decreases fibrotic areas, increases gland numbers, stimulates angiogenesis, and enhances endometrial reconstruction and via supports pregnancy and improves pregnancy rates via a desirable formation of uterine tissue. This is probably done by entering into the endometrium and mutual differentiation into the epithelium and stroma or by the immunomodulatory effect and activation of endometrial progenitors through the growth factor.
Conclusion: Medical societies trust the use of stem cells in the treatment of degenerative diseases, cancer, and the repair of tissue damage with limited possibility of improvement. With regard to the recent advancements, there is a hope for the treatment of diseases, such as Ashman syndrome and endometrial atrophy. So, treatment with bone marrow, endometrium, menstrual blood, and cord blood-derived stem cells can help endometrial regeneration and improvement of the disease. In addition, uterine tissue engineering has also raised hopes for the future treatment of uterine diseases with 3D cell growth.

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Article Type: Analytical Review | Subject: Reproduction
Received: 2018/08/14 | Accepted: 2019/08/1 | Published: 2019/08/1

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