Volume 8, Issue 2 (2023)                   SJMR 2023, 8(2): 97-103 | Back to browse issues page

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Alamshah N, Jamaldini S H, Behjati F. Epigenetics Association of Non-coding RNAs with Preeclampsia. SJMR 2023; 8 (2) : 3
URL: http://saremjrm.com/article-1-296-en.html
1- Department of Molecular and Cellular Science, Faculty of Advanced Sciences Branch, Islamic Azad University, Tehran- Iran.
2- Department of Genetic, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
3- Sarem gynecology, Obstetrics and Infertility Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Genetics Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Abstract:   (625 Views)
Preeclampsia (PE) is one of the severe complications of pregnancy that includes 3-5% of all pregnancies. This disorder in the functioning of the maternal organs or the placenta shows itself after the 20th week of pregnancy and is the cause of 10-15% of the deaths of pregnant mothers. Despite the progress achieved in the management of this disease in recent years, the main reason for the occurrence of this disease and the methods of early diagnosis and prevention have not been determined. Also, there are currently no clinically predictive biomarkers for preeclampsia. Recently, researchers have linked epigenetic factors with this disease. Non-coding RNAs, including miRNAs and long non-coding RNAs (lncRNAs), are epigenetic factors that play a role in the regulation of multiple cellular functions and are therefore widely investigated as potential biomarkers for various diseases. Altered expression of many lncRNAs and miRNAs in placenta is associated with pathophysiological processes occurring in preeclampsia. In this review article, various aspects of epigenetics on preeclampsia have been investigated.
Article number: 3
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Article Type: Systematical Review | Subject: Childbirth
Received: 2023/07/10 | Accepted: 2023/08/16 | Published: 2023/12/23

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