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Pashootan N, Derogar P, Mohammadi S, Sadat Shirazi S R, Moharram T. The effect of chemotherapy drugs on male germ cells and fertility in men. SJMR 2022; 7 (1) : 5
URL: http://saremjrm.com/article-1-258-fa.html
URL: http://saremjrm.com/article-1-258-fa.html
پشوتن نسرین، دروگر پریسا، محمدی سمانه، سادات شیرازی سیده راضیه، محرمی تموچین. اثر داروهای شیمی درمانی بر سلول های زایای مردانه و باروری در مردان. مجله تحقيقات پزشكي صارم. 1401; 7 (1) :41-53
نسرین پشوتن* 
1، پریسا دروگر2 ، سمانه محمدی2 ، سیده راضیه سادات شیرازی2 ، تموچین محرمی2
1، پریسا دروگر2 ، سمانه محمدی2 ، سیده راضیه سادات شیرازی2 ، تموچین محرمی2
1- مرکز تحقیقات زنان، زایمان و ناباروری صارم، بیمارستان فوق تخصصی صارم، دانشگاه علوم پزشکی ایران، تهران، ایران. ، saremcrc@gmail.com
2- مرکز تحقیقات زنان، زایمان و ناباروری صارم، بیمارستان فوق تخصصی صارم، دانشگاه علوم پزشکی ایران، تهران، ایران.
2- مرکز تحقیقات زنان، زایمان و ناباروری صارم، بیمارستان فوق تخصصی صارم، دانشگاه علوم پزشکی ایران، تهران، ایران.
چکیده: (2769 مشاهده)
مقدمه: در طول چند دهه ی گذشته، به لطف پیشرفت در تشخیص و درمان، تعداد بازماندگان سرطان افزایش یافته است. درمان‌های سرطان بسته به سن بیمار، نوع سرطان، رژیم درمانی و دوز داروها اغلب با عوارض جانبی بسیاری همراه می باشد. یکی از مهمترین عوارض بخصوص در سرطان های بیضه و پروستات در مردان، مشکلات ناباروری بعد از درمان سرطان است. بافت بیضه به شیمی درمانی و رادیوتراپی بسیار حساس است. اثرات مضر شیمی درمانی بر روی سلول های زایا به عوامل بسیاری از جمله پارامترهای اولیه ی مایع منی، نحوه ی تجویز دارو، نوع و دوز رژیم های شیمی درمانی و مرحله اسپرم زایی در طول زمان تجویز دارو بستگی دارد. متاسفانه مطالعات بالینی در انسان دشوار هستند زیرا درمان های سرطان اغلب ترکیبی از شیمی درمانی و رادیوتراپی می باشند.
نتیجه گیری: بنابراین، انجام مطالعات تجربی در مدل های حیوانی به منظور تعریف مکانیسم دخیل در سمیت گناد و دارو مهم است تا اثرات تجویز آن ها به تنهایی یا به صورت ترکیبی بر روی بیضه های بالغ و نابالغ ارزیابی گردد. این داده ها به اطلاع بهتر بیماران سرطانی پس از بهبودی در مورد خطرات شیمی درمانی برای باروری آینده آن ها و پیشنهاد گزینه های حفظ باروری کمک می کند. در این بررسی، ما به مرور نحوه ی اثر و عوارض جانبی برخی از داروهای شیمی درمانی بر باروری در مردان می پردازیم.
نتیجه گیری: بنابراین، انجام مطالعات تجربی در مدل های حیوانی به منظور تعریف مکانیسم دخیل در سمیت گناد و دارو مهم است تا اثرات تجویز آن ها به تنهایی یا به صورت ترکیبی بر روی بیضه های بالغ و نابالغ ارزیابی گردد. این داده ها به اطلاع بهتر بیماران سرطانی پس از بهبودی در مورد خطرات شیمی درمانی برای باروری آینده آن ها و پیشنهاد گزینه های حفظ باروری کمک می کند. در این بررسی، ما به مرور نحوه ی اثر و عوارض جانبی برخی از داروهای شیمی درمانی بر باروری در مردان می پردازیم.
شماره‌ی مقاله: 5
واژه‌های کلیدی: سرطان، ناباروری، شیمی درمانی، رادیو تراپی، مایع منی
نوع مقاله: مروری تحلیلی |
موضوع مقاله:
ناباروری
دریافت: 1401/11/30 | پذیرش: 1401/11/30 | انتشار: 1401/11/30
دریافت: 1401/11/30 | پذیرش: 1401/11/30 | انتشار: 1401/11/30
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