Volume 9, Issue 1 (2024)
SJMR 2024, 9(1): 5-11 |
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Nateghi M R, Amini Mahabadi J. The use of snake venom in cancer treatment: a review study. SJMR 2024; 9 (1) : 2
URL: http://saremjrm.com/article-1-250-en.html
URL: http://saremjrm.com/article-1-250-en.html
1- Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
2- Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
2- Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
Abstract: (1942 Views)
Introduction: Snake venom is an oily liquid, depending on the type of snake, it is white to bright yellow, transparent or cloudy and slightly acidic. Snake venom is a mixture of complex protein substances with chemical and enzymatic properties and non-protein substances. Snake venom is a folk medicine that has been used since ancient times. Biochemically, snake venom is a complex mixture of medicinally active proteins and polypeptides. Snake venom usually contains 30 to 100 venom proteins, some of these proteins have enzymatic activity, while others are non-enzymatic. There are about 26 types of enzymes in snake venom. About 90 to 92% of the dry weight of poison is composed of protein substances, some of which affect the nervous system. Some of them change the permeability of the cell and others cause the destruction of muscle fibers. The purpose of this article is to review recent findings on the use of snake venom as an anticancer agent
Conclusion: Snake venom has the highest toxicity potential and is an attractive option in the development of anti-cancer agents. Usually, traditionally used anticancer drugs have unwanted side effects. Venomous animals secrete poison from certain parts of their body. Due to the anticancer activities of choice, these naturally derived compounds will be of great importance in the field of cancer. Snake venom is a combination of biologically active components that play a role not only in the pathophysiology of detoxification, but also in the development of new drugs for the treatment of many diseases. Snake venom produces antitumor, antimicrobial, analgesic, antiplatelet, blood pressure lowering, etc. activities. Today, using special isolation and formulation techniques, some purified snake venom components are used for their potential to treat acute and chronic conditions, while others are undergoing further clinical trials. Snake venom can be a valuable source of new key components in drug discovery.
Conclusion: Snake venom has the highest toxicity potential and is an attractive option in the development of anti-cancer agents. Usually, traditionally used anticancer drugs have unwanted side effects. Venomous animals secrete poison from certain parts of their body. Due to the anticancer activities of choice, these naturally derived compounds will be of great importance in the field of cancer. Snake venom is a combination of biologically active components that play a role not only in the pathophysiology of detoxification, but also in the development of new drugs for the treatment of many diseases. Snake venom produces antitumor, antimicrobial, analgesic, antiplatelet, blood pressure lowering, etc. activities. Today, using special isolation and formulation techniques, some purified snake venom components are used for their potential to treat acute and chronic conditions, while others are undergoing further clinical trials. Snake venom can be a valuable source of new key components in drug discovery.
Article number: 2
Article Type: Analytical Review |
Subject:
Health and safety
Received: 2023/05/5 | Accepted: 2023/05/15 | Published: 2024/12/4
Received: 2023/05/5 | Accepted: 2023/05/15 | Published: 2024/12/4
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