Volume 7, Issue 2 (2022)
SJMR 2022, 7(2): 87-94 |
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Amini Mahabadi A, Saye naderi M, Nateghi M R. Current status of induced Pluripotent Stem Cells Differentiation into Sperm and Oocyte as a Therapy Method for Infertility: Advantages and Disadvantages. SJMR 2022; 7 (2) :87-94
URL: http://saremjrm.com/article-1-262-en.html
URL: http://saremjrm.com/article-1-262-en.html
1- Responsible for administrative affairs, Payame Noor University, Ardestan, Isfahan, Iran
2- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
3- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran , dr.mr.nateghi@gmail.com
2- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
3- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran , dr.mr.nateghi@gmail.com
Abstract: (599 Views)
Introduction: Infertility is a major public health concern that affects 10-15% of reproductive age couples in the world. Male factors are mainly due to sperm morphological and functional disorders, including premature puberty, hereditary diseases and structural problems such as testicular obstruction, damage to the reproductive system leading to sperm dysfunction, and environmental and psychological factors. While, factors related to women are ovulation disorder, abnormal uterus or fallopian tubes, endometritis, primary ovarian failure and pelvic adhesions. According to this research, stem cells under certain conditions can differentiate into germ cells, which can be a way to treat infertility.
Conclusion: Researchers worldwide are doing their best to standardize differentiation protocols to achieve safer and more favorable results. However, before we can look forward to their use in humans, much effort will still be required to successfully create fully functional, viable offspring from in vitro differentiated in vitro cells.
Conclusion: Researchers worldwide are doing their best to standardize differentiation protocols to achieve safer and more favorable results. However, before we can look forward to their use in humans, much effort will still be required to successfully create fully functional, viable offspring from in vitro differentiated in vitro cells.
Article number: 3
Article Type: Analytical Review |
Subject:
Women Diseases
Received: 2022/07/1 | Accepted: 2022/07/12 | Published: 2023/03/7
Received: 2022/07/1 | Accepted: 2022/07/12 | Published: 2023/03/7
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