Volume 4, Issue 1 (2020)                   SJRM 2020, 4(1): 1-1 | Back to browse issues page

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Nazempour A, Saremi A. Evaluation of the effect of clomiphene citrate therapy on fertility success rate in infertile patients with ovulatory factors in Sarem hospital 1394-1396.. SJRM. 2020; 4 (1) :1-1
URL: http://saremjrm.com/article-1-133-en.html
1- Specialty , aninzm@yahoo.com
2- Sarem Fertility and Infertility Research Center
Abstract:   (241 Views)
  • Ovarian factor is one of the most common causes of  infertility in couples and various therapeutic methods have been adopted for its treatment. Clomiphene citrate is one of the safe and low cost medicine  with a high response rate in these individuals. This drug is used with or without gonadotropins or with or without IUI in subfertile or infertile couples with ovulatory factor .
Materials and Methods: This article is a retrospective cross-sectional study in which the results of treatment with clomiphene with or without IUI in sub-fertile or infertile patients with ovulatory factor that  referred to Sarem women’s hospital during 2015-2017  were investigated. This study was performed on 785 electronic patients records, and in all of them Serum levels of  (LH, FSH, TSH, PRL, E2 and AMH) in the third day of the menstrual cycle were measured  and then clomiphene therapy has begun  From the fifth day the menstrual cycle. In all of the patients, the spermogram was performed in two steps, which the result was in normal range after the capacitance (sperm processing).
Results: The results of this study showed that there is no significant relationship between type of menstruation and type of treatment protocol used for patients (P = 0.109). There was also no significant relationship between acne and hirsutism in patients and type of treatment protocol (P = 0.281) and (P = 0.223). Also, there was no significant relationship between clomiphene or clomiphene treatment with IUI and LH (P = 0.783), FSH (P = 0. 516), AMH (P = 0.679) and PRL (P = 0.345), and there is no significant relationship between BMI (P = 0/584) and type of patient's treatment.
Treatment with clomiphene alone did not have a significant effect on the success of pregnancy outcomes, but in the protocol of clomiphene and IUI, in 127 cases the clinical test ofpregnancy were positive, that 3% were ectopic pregnancy, 5% were aborted, andin124 cases lead to the birth of a newborn, which based on theseresults Statistical analysis showed a significant relationship (P = 0.036).
  • Clomiphene, as a low-dose, effective and available drug, can be used as an appropriate treatment for the treatment of infertile patients with ovarian factor in combination with IUI therapy. In comparison to other medicines clomiphene has lower cost and side effects, which make it an appropriate treatment option.
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Article Type: Brief Communication | Subject: Reproduction
Received: 2018/12/19 | Accepted: 2020/03/27 | Published: 2020/03/27

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