Volume 3, Issue 1 (2018)                   SJMR 2018, 3(1): 73-78 | Back to browse issues page

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Roostaee Z. Effect of Alkaloids Belong to β-Carbolines Family in Peganum Harmala on Cancer Cells. SJMR 2018; 3 (1) :73-78
URL: http://saremjrm.com/article-1-99-en.html
Effect of Alkaloids Belong to β-Carbolines Family in Peganum Harmala on Cancer Cells
Z. Roostaee *
Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran , zrmj1394@gmail.com
Abstract:   (8392 Views)

Introduction: As a herb, Peganum harmala has been important in traditional medicine for a long time. Some studies have shown the inhibitory effect of many plant compounds, including alkaloids belonging to β-carboline family, on cancer cells. This plant contains important alkaloids, such as Harmaline, Harmine, Harmane, and some other components of -carboline family. The literature in this field shows that various concentrations of the alkaloids are effective in treating various diseases, including inhibition of cancer cells. The aim of this study was to introduce Peganum harmala as one of the natural potentials of Iran in relation to herbs and its pharmacological effects. In this study, the keywords Peganum harmala, pathway of betacarbolins in the human body, betacarbolins, Toxicity, and Anti-cancer were searched in Elsevier, PubMed, and Google Scholar databases and the related articles were provided. Then, in advanced search, the pharmacological effects of Peganum harmala, apoptosis, and the mechanism of analgesic effects were searched both in Persian and in English. Finally, 30 articles related to Peganum harmala in traditional medicine were downloaded, translated, and all articles underwent content analysis.
Conclusion: As one of the most important herbs with valuable alkaloids belonging to the β-carboline family, African rue "Peganum harmala” can produce compounds against cancer cells that can be effective in the treatment of cancer. The review of the studies has also shown that the plant extract is effective in preventing the progression of cancer cells.

Keywords: Peganum Harmala, β-Carboline, Alkaloids, Pharmacology, Cancer
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Article Type: Systematical Review | Subject: Reproduction
Received: 2017/01/24 | Accepted: 2017/04/21 | Published: 2018/05/22
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