Volume 3, Issue 4 (2019)                   SJMR 2019, 3(4): 25-31 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Roumandeh N, Saremi A, Zare A. Immunology of Endometriosis; a Systematic Review. SJMR 2019; 3 (4) :25-31
URL: http://saremjrm.com/article-1-85-en.html
1- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
2- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran , zare-a@alumnus.tums.ac.ir
Abstract:   (5308 Views)

Introduction: Endometriosis is a common and gynecologic illness affecting women in reproductive age and characterized by the growth of endometrial-like tissue and stroma outside the uterine cavity. It is also a significant cause of infertility. The cause of endometeriosis is still unclear but an increasing number of studies have been investigated the role of immune system in its etiology and pathogenesis. So, it is well known that endometriosis is an inflammatory disease and has dysfunction in patient’s immune response. The development of endometriosis may be influenced by immune factors including formation of autoantibodies, impaired immune recognition and clearance of ectopic endometrial cells. In this review, we will summarize the current knowledge about immunological factors in women with endometriosis that provide the basis for developing new approaches to patient management. In this review, the basic contents were obtained from textbooks and new surveies were searched from pubmed, science direct and google scholar in the period of 1980-2015.

Conclusion: Immunological factors have been considered as important factors in the prevention and treatment of endometriosis. In addition, clinical studies are recommended to understanding the mechanism and the role of immunological factors in the prevention and treatment of endometriosis.

Full-Text [PDF 609 kb]   (2474 Downloads)    
Article Type: Systematical Review |
Received: 2017/07/12 | Accepted: 2017/09/28 | Published: 2019/01/4

References
1. Dmowski WP, Braun DP. Immunology of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2004;18(2):245-63. [Link] [DOI:10.1016/j.bpobgyn.2004.02.001] [PMID]
2. Thiruchelvam U, Wingfield M, O'Farrelly C. Natural killer cells: Key players in endometriosis. Am J Reprod Immunol. 2015;74(4):291-301. [Link] [DOI:10.1111/aji.12408] [PMID]
3. Zeller JM, Henig I, Radwanska E, Dmowski WP. Enhancement of human monocyte and peritoneal macrophage chemiluminescence activities in women with endometriosis. Am J Reprod Immunol. 1987;13(3):78-82. [Link] [DOI:10.1111/j.1600-0897.1987.tb00097.x]
4. Braun DP, Gebel H, House R, Rana N, Dmowski NP. Spontaneous and induced synthesis of cytokines by peripheral blood monocytes in patients with endometriosis. Fertil Steril. 1996;65(6):1125-9. [Link] [DOI:10.1016/S0015-0282(16)58325-3]
5. Braun DP, Ding J, Dmowski WP. Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-alpha in women with endometriosis. Fertil Steril. 2002;78(4):727-32. [Link] [DOI:10.1016/S0015-0282(02)03318-6]
6. Vinatier D, Dufour P, Oosterlynck D. Immunological aspects of endometriosis. Hum Reprod Update. 1996;2(5):371-84. [Link] [DOI:10.1093/humupd/2.5.371]
7. Santanam N, Song M, Rong R, Murphy AA, Parthasarathy S. Atherosclerosis, oxidation and endometriosis. Free Radic Res. 2002;36(12):1315-21. [Link] [DOI:10.1080/1071576021000049908]
8. Braun DP, Gebel H, Rotman C, Rana N, Dmowski WP. The development of cytotoxicity in peritoneal macrophages from women with endometriosis. Fertil Steril. 1992;57(6):1203-10. [Link] [DOI:10.1016/S0015-0282(16)55074-2]
9. Kwak JY, Park SW, Kim KH, Na YJ, Lee KS. Modulation of neutrophil apoptosis by plasma and peritoneal fluid from patients with advanced endometriosis. Hum Reprod. 2002;17(3):595-600. [Link] [DOI:10.1093/humrep/17.3.595]
10. Schulke L, Berbic M, Manconi F, Tokushige N, Markham R, Fraser IS. Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis. Hum Reprod. 2009;24(7):1695-703. [Link] [DOI:10.1093/humrep/dep071] [PMID]
11. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril. 2001;75(1):1-10. [Link] [DOI:10.1016/S0015-0282(00)01630-7]
12. D'Cruz OJ, Uckun FM. Targeting mast cells in endometriosis with janus kinase 3 inhibitor, JANEX-1 Am J Reprod Immunol. 2007;58(2):75-97. [Link] [DOI:10.1111/j.1600-0897.2007.00502.x] [PMID]
13. Startseva NV. Clinical immunological aspects of genital endometriosis. Akush Ginekol (Mosk). 1980;(3):23-6. [Russian] [Link]
14. Isaacson KB, Xu Q, Lyttle CR. The effect of estradiol on the production and secretion of complement component 3 by the rat uterus and surgically induced endometriotic tissue. Fertil Steril. 1991;55(2):395-402. [Link] [DOI:10.1016/S0015-0282(16)54135-1]
15. Gleicher N, el-Roeiy A, Confino E, Friberg J. Is endometriosis an autoimmune disease?. Obstet Gynecol. 1987;70(1):115-22. [Link] [PMID]
16. Meek SC, Hodge DD, Musich JR. Autoimmunity in infertile patients with endometriosis. Am J Obstet Gynecol. 1988;158(6 Pt 1):1365-73. [Link] [DOI:10.1016/0002-9378(88)90369-9]
17. Weed JC, Arquembourg PC. Endometriosis: can it produce an autoimmune response resulting in infertility?. Clin Obstet Gynecol. 1980;23(3):885-93. [Link] [DOI:10.1097/00003081-198023030-00018]
18. Mathur S, Peress MR, Williamson HO, Youmans CD, Maney SA, Garvin AJ, et al. Autoimmunity to endometrium and ovary in endometriosis. Clin Exp Immunol. 1982;50(2):259-66. [Link] [PMID] [PMCID]
19. Mathur SP. Autoimmunity in endometriosis: Relevance to infertility. Am J Reprod Immunol. 2000;44(2):89-95. [Link] [DOI:10.1111/j.8755-8920.2000.440204.x]
20. Ota H, Igarashi S, Hatazawa J, Tanaka T. Is adenomyosis an immune disease?. Hum Reprod Update. 1998;4(4):360-7. [Link] [DOI:10.1093/humupd/4.4.360]
21. Dmowski WP, Rana N, Michalowska J, Friberg J, Papierniak C, el-Roeiy A. The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates. Fertil Steril. 1995;63(3):555-62. [Link] [DOI:10.1016/S0015-0282(16)57425-1]
22. Nothnick WB. Treating endometriosis as an autoimmune disease. Fertil Steril. 2001;76(2):223-31. [Link] [DOI:10.1016/S0015-0282(01)01878-7]
23. Dmowski WP, Steele RW, Baker GF. Deficient cellular immunity in endometriosis. Am J Obstet Gynecol. 1981;141(4):377-83. [Link] [DOI:10.1016/0002-9378(81)90598-6]
24. Kralickova M, Vetvicka V. Immunological aspects of endometriosis: A review. Ann Transl Med. 2015;3(11):153. [Link] [PMID] [PMCID]
25. Gogacz M, Winkler I, Bojarska-Junak A, Tabarkiewicz J, Semczuk A, Rechberger T, et al. T regulatory lymphocytes in patients with endometriosis. Mol Med Rep. 2014;10(2):1072-6. [Link] [DOI:10.3892/mmr.2014.2294] [PMID]
26. Miossec P, Korn T, Kuchroo VK. Interleukin-17 and type 17 helper T cells. N Engl J Med. 2009;361(9):888-98. [Link] [DOI:10.1056/NEJMra0707449] [PMID]
27. Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008;223:87-113. [Link] [DOI:10.1111/j.1600-065X.2008.00628.x] [PMID] [PMCID]
28. Hirata T, Osuga Y, Takamura M, Kodama A, Hirota Y, Koga K, et al. Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells. Endocrinology. 2010;151(11):5468-76. [Link] [DOI:10.1210/en.2010-0398] [PMID]
29. Olovsson M. Immunological aspects of endometriosis: an update. Am J Reprod Immunol. 2011;66(Suppl 1):101-4. [Link] [DOI:10.1111/j.1600-0897.2011.01045.x] [PMID]

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | {Sarem Journal of Medical Research}

Designed & Developed by : Yektaweb