Volume 2, Issue 3 (2017)                   SJRM 2017, 2(3): 145-152 | Back to browse issues page


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Saremi A, Namdar Khanzadeh M, Shami M, Mohammad Aliha F, Pooladi A. The Efficacy of Mannitol Therapy in the Management of Moderate and Severe Forms of Ovarian Hyperstimulation Syndrome: A New Application. SJRM. 2017; 2 (3) :145-152
URL: http://saremjrm.com/article-1-42-en.html
1- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran , saremiat@yahoo.com
2- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
3- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Abstract:   (4737 Views)

Aims: Ovarian hyperstimulation syndrome (OHSS) is an important complication of assisted reproductive technique (ART) following ovulation stimulation. Based on the disease pathophysiology and the mechanisms of drug effectiveness, mannitol was selected as an alternative for albumin. The objective of this study was to evaluate the efficacy of mannitol therapy in the management of moderate and severe forms of OHSS.
Materials and Methods: This interventional non-experimental study was conducted on patients with moderate and severe OHSS over a period of 19 years (1994-2013). A total of 6970 women entered the ovarian stimulation protocol for IVF. All patients at risk for OHSS received a preventive dose of mannitol. If the patients developed signs of moderate/severe OHSS, they included in the study. Mannitol therapy was started daily or twice a day using doses ranged between 1 to 1.5 g/kg/dose. Patients were monitored according to the standard protocols. Data were analyzed by SPSS 19 software.
Findings: OHSS developed in 1737 (24.92%) women. Mild OHSS was found in 1360 (78.30%), moderate in 338 (19.46%), and severe in 39 (2.24%) patients. A significant weight loss (p=0.024) was found after mannitol therapy. The correction of mean intake/output (I/O) balance of fluids (p=0.009) showed significant difference before and after mannitol therapy. Mean duration of hospitalization was 4.72±2.24 days, and the mortality rate was 0.0%.
Conclusion: Mannitol therapy is an effective protocol in the management of moderate and severe forms of OHSS.

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Article Type: Original Research | Subject: Sterility
Received: 2016/04/3 | Accepted: 2016/10/20 | Published: 2017/11/16

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