Volume 11, Issue 1 (2026)
SJMR 2026, 11(1): 1-3 |
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Saremi A. Studying the Differentiation Effect of Induced Pluripotent Stem Cells (iPSCs) into Germ Cells. SJMR 2026; 11 (1) : 1
URL: http://saremjrm.com/article-1-386-en.html
URL: http://saremjrm.com/article-1-386-en.html
Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
Abstract: (258 Views)
In recent years, significant advances in the field of stem cell biology, especially the development of induced pluripotent stem cell (iPSC) technology, have provided new avenues for studying germ cell development and their clinical applications. These cells, which are obtained from somatic cell reprogramming, have similar properties to embryonic stem cells, including the ability to self-renew and differentiate into all three germ layers. These properties have made them an attractive option for disease modeling, regenerative medicine, and especially infertility treatment [1]. The process of differentiating iPSCs into germ cells is a complex and multi-step process that is attempted to be recreated in vitro, similar to the natural pathway of gametogenesis. This process usually involves two major steps: first, differentiation into primary germ-like cells (PGC-LCs) and then entry of these cells into meiosis and formation of mature germ cells. Although the generation of PGC-LCs has been relatively successful in various studies, the full induction of meiosis and the production of functional gametes still face major challenges [2, 3].
Article number: 1
Article Type: Letter to Editor |
Subject:
Reproduction
Received: 2026/02/4 | Accepted: 2026/03/16 | Published: 2026/05/19
Received: 2026/02/4 | Accepted: 2026/03/16 | Published: 2026/05/19
References
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