Volume 10, Issue 4 (2025)
SJMR 2025, 10(4): 227-233 |
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Talebian N. A Review of Novel Stem Cell-Based Strategies for The Treatment of Azoospermia. SJMR 2025; 10 (4) : 8
URL: http://saremjrm.com/article-1-385-en.html
URL: http://saremjrm.com/article-1-385-en.html
Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences, Tehran, Iran. & IVF Embryology Laboratory, Sarem Women’s Hospital.
Abstract: (394 Views)
Background: Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and retaining features of their source cells. The rate of infertility has globally increased in recent years for a variety of reasons. One of the main causes of infertility in men is azoospermia that is defined by the absence of sperm in the ejaculate and classified into two categories: obstructive azoospermia and non-obstructive azoospermia. In non-obstructive azoospermia, genital ducts are not obstructed, but the testicles do not produce sperm at all, due to various reasons. Non-obstructive azoospermia in most cases has no therapeutic options other than assisted reproductive techniques. Nonobstructive azoospermia (NOA) is a reproductive disease in men that causes infertility in 10% of infertile men. Based on in vitro studies, MSCs from different tissue sources have been differentiated into germ cells or gamete progenitor cells by simple methods in both male and female. This minireview explores the current landscape of stem cell therapy for azoospermia, focusing on the potential and challenges associated with Mesenchymal Stem Cells (MSCs). MSCs emerge as a promising avenue for male infertility treatment.
Conclusion: The conclusion emphasizes the necessity for continued research and clinical trials to unlock the full potential of MSC therapy in addressing the complexities of azoospermia. Stem cell-based treatment of non-obstructive azoospermia is a novel and promising therapeutic approach aimed at improving spermatogenesis in damaged testes.
Conclusion: The conclusion emphasizes the necessity for continued research and clinical trials to unlock the full potential of MSC therapy in addressing the complexities of azoospermia. Stem cell-based treatment of non-obstructive azoospermia is a novel and promising therapeutic approach aimed at improving spermatogenesis in damaged testes.
Article number: 8
Keywords: Azoospermia, male infertility, non-obstructive azoospermia, mesenchymal stem cells, cell therapy.
Article Type: Analytical Review |
Subject:
Sterility
Received: 2026/02/14 | Accepted: 2026/03/1 | Published: 2026/03/12
Received: 2026/02/14 | Accepted: 2026/03/1 | Published: 2026/03/12
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