Volume 10, Issue 4 (2025)                   SJMR 2025, 10(4): 175-178 | Back to browse issues page


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Saremi A. The Role of Mesenchymal Stem Cells in the Treatment of Asherman’s Syndrome and Endometriosis: Emerging Horizons in Reproductive Regenerative Medicine. SJMR 2025; 10 (4) : 1
URL: http://saremjrm.com/article-1-346-en.html
Sarem Gynecology, Obstetrics and Infertility Research Center, Sarem Women’s Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
Abstract:   (12 Views)
Abstract: Asherman’s syndrome and endometriosis are two major and complex gynecologic disorders that have long drawn the attention of researchers and clinicians due to their profound implications for fertility, uterine function, and patients’ quality of life [1,2]. In Asherman’s syndrome, endometrial injury and the formation of intrauterine adhesions lead to severe disruption of the architecture and function of the basal endometrium, resulting in endometrial thinning, amenorrhea or oligomenorrhea, and infertility. Although hysteroscopic adhesiolysis remains the standard treatment and offers considerable benefits, it is often insufficient for restoring the regenerative capacity of the endometrium in patients with severe adhesions or extensive basal layer damage [3].
Article number: 1
Full-Text [PDF 330 kb]   (14 Downloads)    
Article Type: Analytical Review | Subject: Women Diseases
Received: 2025/11/6 | Accepted: 2025/12/6 | Published: 2025/12/10

References
1. Obeagu, E. I. & Obeagu, G. U. Hematological factors in women with Asherman syndrome and primary infertility: An overview. Medicine 104, e45562, doi:10.1097/md.0000000000045562 (2025). [DOI:10.1097/MD.0000000000045562] [PMID] []
2. Awano-Kim, S., Hosoya, S., Yokomizo, R., Kishi, H. & Okamoto, A. Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells. Regenerative Therapy 29, 328-340, doi: https://doi.org/10.1016/j.reth.2025.03.019 [DOI:10.1016/j.reth.2025.03.019 (2025).] [PMID] []
3. Mahmoodinia, M. & Roustaie, M. Role of Stem Cells in the Future of Asherman Syndrome Treatment. Sarem Journal of Medical Research 4, 87-92, doi:10.29252/sjrm.4.2.87 (2019). [DOI:10.29252/sjrm.4.2.87]
4. Mariadas, H., Chen, J. H. & Chen, K. H. The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications. International journal of molecular sciences 26, doi:10.3390/ijms26062458 (2025). [DOI:10.3390/ijms26062458] [PMID] []
5. Nateghi, M. R. & Amini Mahabadi, J. Investigating the expression of mesenchymal stem cell markers in human bone marrow stem cells. Sarem Journal of Medical Research 7, 165-170, doi:10.61186/sjrm.7.3.165 (2022). [DOI:10.61186/sjrm.7.3.165]
6. Zhou, L. et al. Stem cells implanted with nanofibrous mats for injured endometrial regeneration and immune-microenvironment remodeling. Materials Today Bio 23, 100855, doi: https://doi.org/10.1016/j.mtbio.2023.100855 [DOI:10.1016/j.mtbio.2023.100855 (2023).] [PMID] []
7. Hou, C., Zhu, H. & Chang, X. Mesenchymal stem cells: opening a new chapter in the treatment of gynecological diseases. Stem cell research & therapy 16, 520, doi:10.1186/s13287-025-04623-9 (2025). [DOI:10.1186/s13287-025-04623-9] [PMID] []

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