Introduction: Evidence indicates that it has long been considered public health and the observance of pilgrims and the poor people near the Haram of Imam Reza, sometimes it was called "Darulshafa", and the founders were those good people who were trying to provide as much as possible the facilities for the welfare of sick and poor people.
Conclusion: In Teimori period, Goharshad Khatun founded a Darulshafa nearby the Haram at the time of establishing the Goharshad Mosque. In addition, in Safavieh period there used to be other Darulshafa which received several devotions which the most apparent one was Atighi devotion. In Afshar period, Adelshah repaired Imam Reza Darulshafa and devoted part of his property to it. In Ghajarieh period, Mirza Jafarkhan Moshiroldoleh founded a new type of Darulshafa. After the First World War, Dr. Amir Alam in his trip to Mashhad by presenting a report to Ahmadshah, took action to fundamental reforms in the organization and income of Darulshafa. He also intended to isolate the male and female section of Darulshafa completely. In 1933, Imam Reza Hospital was established by Mohammad Ali Asadi and its second head of the hospital was Professor Hammer Shelak who himself was a obstetrician. Since 1937, the Nursing School was established under the supervision of foreign nurses in this hospital until it was handed over to Iranian nurses in 1941. Now Astan Quds Razavi by having 1048 endowments is one of the biggest endowments in Islamic world.