Volume 1, Issue 2 (2017)                   SJRM 2017, 1(2): 55-58 | Back to browse issues page


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Saremi A, Fasihi F, Marmazi F, Safavi M, Hakak N, Ghanbari Torshaki F. Postmenopausal Hormone Therapy Effect on Atherogenic Factors and Chylomicrons Levels. SJRM. 2017; 1 (2) :55-58
URL: http://saremjrm.com/article-1-30-en.html
1- Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran , saremiat@yahoo.com
2- ‎“Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem ‎Women’s Hospital, Tehran, Iran
3- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
4- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Abstract:   (20926 Views)

Aims: Cardiovascular diseases are one of the most important complications in menopausal period. The complications are one of the major causes of death in women. Clearance of chylomicrons increases with hormone replacement therapy (HRT) that is a protective effect of estrogen against cardiovascular diseases. The objective of this study was to evaluate the postmenopausal hormone therapy effects on atherogenic factors and chylomicron levels.
Materials & Methods: This study was conducted on all women with complications of menopause or womenchr('39')s problems who referred to Sarem medical center during 6 month from 1999 to 2000. The lipid and lipoprotein factors were measured before HRT therapy and six months after the treatment. Data were collected by a questionnaire including demographics, blood pressure, weight, height, and other clinical data. The total cholesterol, triglyceride, HDL, LDL, risk factor (RF), atherogenic factor (AI) and hormonal tests were evaluated before and after treatment. The data were analyzed by Wilcoxon and t tests.
Findings: There were significant relationships between HRT with the increase of HDLC, and reduction of LDLC, RF and AI (p<0.05). However, there were no significant relationships between HRT and triglyceride and cholesterol serum levels.
Conclusion: Hormone therapy increases HDLC and decreases LDLC, RF, and AI, and thus reduces the risk of cardiovascular diseases in postmenopausal women.

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Article Type: Analytical Review | Subject: Sterility
Received: 2016/02/4 | Accepted: 2016/02/22 | Published: 2017/05/15

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