Volume 2, Issue 1 (2017)                   SJMR 2017, 2(1): 43-48 | Back to browse issues page


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Zaker Bostanabad S, Rahimi M, Mahdavi Z, Pourazar S. Evaluation of Cytomegalovirus (CMV) in Abortion Compared with Embryos Vaginal Delivery by Using PCR. SJMR 2017; 2 (1) :43-48
URL: http://saremjrm.com/article-1-28-en.html
1- Biological Sciences Faculty, Parand Branch, Isalmic Azad University, Tehran, Iran , saeedzaker20@yahoo.com
2- Medicine Faculty, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
3- Molecular Department, Khatam Hospital, Tehran, Iran
4- Molecular Department, “Masoud Lab” and “Sarem Women’s Hospital”, Tehran, Iran
Abstract:   (7904 Views)

Aims: Cytomegalovirus is a major cause of congenital abnormalities, mental retardation, abortion and neonatal infections. The aim of this study was to determine the prevalence of CMV in amniotic fluid by PCR method and to compare it between the patients with abortion and women with normal delivery.
Materials & Methods: This case-control and descriptive-analytic study was conducted on 120 women referred to Amiralmomenin, Javaheri and Bouali hospitals in 2010. The women were studied in two case (n=60) and a control (n=60) groups including the mothers with abortions and mothers with normal delivery, respectively. The information of the participants was collected using a questionnaire and a PCR method was used for microbiological examination for CMV. Data were analyzed by SPSS 13 using chi-square test.
Findings: Totally, the PCR results were positive in 16 (13.3%) patients. In the case group, 26.7% of the women had a history of CMV. The PCR results were negative for the control group. Totally, the prevalence of CMV was 13.3%. In the case group, 61.7% of patients had no abortion history, 30.0% had one abortion and 8.3% had two abortions, previously. In the case group, abortions occurred before 20 weeks of gestation in 21.7% of women and 78.3% of abortions occurred after 21 weeks of pregnancy. There was a significant relationship between the incidence of CMV and the number of abortions in the mothers and abortion time.
Conclusion: Due to the importance of rapid and correct diagnosis of pathogens before emergence of its complications, the molecular method can be useful for the purpose and even for the low level of pathogenicity.

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Article Type: Analytical Review | Subject: Sterility
Received: 2016/02/20 | Accepted: 2016/05/19 | Published: 2017/06/20

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