Volume 7, Issue 1 (2022)
SJMR 2022, 7(1): 41-53 |
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Pashootan N, Derogar P, Mohammadi S, Sadat Shirazi S R, Moharram T. The effect of chemotherapy drugs on male germ cells and fertility in men. SJMR 2022; 7 (1) : 5
URL: http://saremjrm.com/article-1-258-en.html
URL: http://saremjrm.com/article-1-258-en.html
Nasrin Pashootan * 
1, Parisa Derogar2 , Samaneh Mohammadi2 , Seyede Razie Sadat Shirazi2 , Tamouchin Moharram2
1, Parisa Derogar2 , Samaneh Mohammadi2 , Seyede Razie Sadat Shirazi2 , Tamouchin Moharram2
1- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. , saremcrc@gmail.com
2- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
2- Sarem gynecology, Obstetrics and Infertilty Research Center, Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
Abstract: (2203 Views)
Introduction: During the past few decades, as a result of progress in the diagnosis and treatment, the number of cancer survivors has increased. Cancer treatments often have many side effects, depending on the patient's age, type of cancer, treatment regimen, and dose of medication. One of the most important complications following treatment, especially in testicular and prostate cancers in men, is infertility. Testicular tissue is very sensitive to chemotherapy and radiotherapy. The harmful effects of chemotherapy on germ cells depend on many factors, including the initial parameters of semen, method of drug administration, the type and dose of chemotherapy regimens, and the stage of spermatogenesis at the time of drug administration. Unfortunately, clinical researches in humans are difficult because cancer treatments are often a combination of chemotherapy and radiotherapy.
Conclusion: Hence, experimental studies in animal models are important in order to define the mechanism involved in the toxicity effects on gonads and the drugs used. This would help the evaluation of the effects of drug administration alone or in combination on mature and immature testes. These data will provide cancer patients with better information, after recovery, regarding the risks of chemotherapy for their future fertility. It would also offer fertility options for the preservation of their fertility. The aim of this study was to evaluate the effects and side complications of some chemotherapy drugs on fertility in men.
Conclusion: Hence, experimental studies in animal models are important in order to define the mechanism involved in the toxicity effects on gonads and the drugs used. This would help the evaluation of the effects of drug administration alone or in combination on mature and immature testes. These data will provide cancer patients with better information, after recovery, regarding the risks of chemotherapy for their future fertility. It would also offer fertility options for the preservation of their fertility. The aim of this study was to evaluate the effects and side complications of some chemotherapy drugs on fertility in men.
Article number: 5
Article Type: Analytical Review |
Subject:
Sterility
Received: 2023/02/19 | Accepted: 2023/02/19 | Published: 2023/02/19
Received: 2023/02/19 | Accepted: 2023/02/19 | Published: 2023/02/19
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