Volume 3, Issue 4 (2019)                   SJRM 2019, 3(4): 149-154 | Back to browse issues page

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Alirezaei M. Correlation between Estradiol Levels and Insulin Resistance in Patients with Polycystic Ovary Syndrome. SJRM. 2019; 3 (4) :149-154
URL: http://saremjrm.com/article-1-139-en.html
1- Sarem Fertility & Infertility Research Center (SAFIR), Iran University of Medical Scienes, Tehran, Iran
Abstract:   (558 Views)
Aims: Polycystic Ovary Syndrome (PCOS) causes metabolic disorders and endocrine disruptions in the body. Serum levels of some hormones in this disease are abnormal, including increased levels of estradiol in the blood. On the other hand, women with PCOS have insulin resistance. The aim of this study was to evaluate the correlation between estradiol and insulin levels in PCOS patients referred to Sarem Hospital.
Instrument & Methods: This descriptive cross-sectional study was performed on 567 patients with PCOS referring to the infertility clinic of Sarem Hospital. Demographic and disease information was collected through a questionnaire and the results were analyzed by SPSS 22 software.
Findings: There was a significant correlation between BMI and fasting (p=0.0001) and 2hpp (p=0.001) insulin. Also a weak and inverse correlation was observed between fasting insulin and prolactin levels (p=0.005). There was a weak correlation between fasting (p=0.004) and 2hpp (p=0.0001) insulin levels and menstrual cycle. There was no statistically significant correlation between serum estradiol levels and fasting and 2hpp insulin (p>0.05).
Conclusion: There is no correlation between blood estradiol levels and insulin resistance and increased fasting and 2hpp blood insulin levels in patients with PCOS that lead to insulin resistance in these individuals cannot be used alone as a criterion of PCOS.
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Article Type: Descriptive & Survey | Subject: Sterility
Received: 2019/02/24 | Accepted: 2019/07/25 | Published: 2020/02/6

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