Volume 3, Issue 3 (2019)                   SJRM 2019, 3(3): 123-126 | Back to browse issues page

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Abdi A, Bagherizadeh I, Vand-Rajabpour V, Shafaghati Y, Behjati F. Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure. SJRM. 2019; 3 (3) :123-126
URL: http://saremjrm.com/article-1-138-en.html
1- “Sarem Fertility & Infertility Reaserch Center (SAFIR)” and “Sarem Cell Research Center & Medical Genetics”, Sarem Women’s Hospital, Tehran, Iran
2- “Sarem Fertility & Infertility Reaserch Center (SAFIR)” and “Sarem Cell Research Center & Medical Genetics”, Sarem Women’s Hospital, Tehran, Iran , fbehjati@gmail.com
Abstract:   (617 Views)
Introduction: Premature ovarian failure (POF) is defined by ovarian failure, amenorrhea, sex steroid deficiency, and elevated (menopausal) levels of serum gonadotropins before the age of 40 years. Chromosome abnormalities are the cause of 5-10% of POF cases. The aim of this study was to report chromosomal abnormalities, with X chromosome involvement, in two patients with POF, referred to Sarem Hospital in Tehran.
Patients’ Information: Two patients with a POF diagnosis were referred to the cytogenetic laboratory of Sarem Hospital in 2014-20115. The chromosomal analysis of a 16-year-old girl and a 26-year-old woman (both with POF) by high resolution GTG banding technique showed structural chromosome abnormities and 46,X,der(X) and 45,dic(X;22)(q22;p12) Karyotypes were observed, respectively.
Conclusion: Cytogenetic investigation in patients with POF is of great value and highly recommended.
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Article Type: Case Report | Subject: Reproduction
Received: 2019/02/10 | Accepted: 2019/04/22 | Published: 2019/04/29

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