Volume 6, Issue 3 (2021)
SJMR 2021, 6(3): 175-183 |
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Amini Mahabadi J, saremi A, Sanaye Naderi M, Moharrami T, Nateghi M R. Vertical transmission of Covid-19 disease through amniotic fluid of mother-to infant: A cross-sectional study. SJMR 2021; 6 (3) : 7
URL: http://saremjrm.com/article-1-238-en.html
URL: http://saremjrm.com/article-1-238-en.html
Javad Amini Mahabadi * 
1, AboTaleb Saremi2 , Maryam Sanaye Naderi1 , Tamouchin Moharrami1 , Mohammad Reza Nateghi2
1, AboTaleb Saremi2 , Maryam Sanaye Naderi1 , Tamouchin Moharrami1 , Mohammad Reza Nateghi2
1- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS) & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS)
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS)
Abstract: (1722 Views)
Introduction: Introduction: The new coronavirus, known as Covid-19, is a highly contagious disease that is spread through the respiratory droplets of infected people. Vertical transmission is the transmission of an infectious pathogen from mother to fetus in the prenatal and postpartum period or to the infant during the postpartum period through the intrauterine placenta, contact of body fluids during childbirth, or through direct contact due to postpartum breastfeeding. This study aimed to investigate the vertical transmission of the disease through amniotic fluid from mother to infant.
Material and methods: In this cross-sectional study, 117 patients participated in the study. All pregnant women had positive RT-PCR results for SARS-CoV-2 RNA. Nasopharyngeal and oropharyngeal swabs were used to detect Covid-19 infection. To perform amniotic fluid sampling, a sterile needle was inserted through the vagina and 10 cc of amniotic fluid was carefully inserted under sterile conditions just before rupture of the membranes and before leakage. Data were statistically analyzed using SPSS software version 24.
Results: There was no difference between the sexes of newborns among the 10 positive amniotic fluid tests compared to the negative cases of this test (P> 0.05). The mean weight of neonates with positive amniotic fluid was 2927 gr. In neonates with negative COVID PCR test in the amniotic fluid; this figure was 3104 gr, which was not statistically significant despite the difference of 117 gr (P> 0.05). Also, there was no statistically significant difference between the two groups, including positive and negative cases of Covid-19 in amniotic fluid test and in parameters including height, weight, heart rate, respiratory rate and minute Apgar score of one and five newborns (P> 0.05).
Conclusion: Because the amniotic fluid is sterile and the placental barrier prevents most microorganisms from passing through, it seems that the Covid-19 virus can cross this barrier in some cases and contaminate the amniotic fluid. However, this infection does not have a significant effect on embryonic parameters.
Material and methods: In this cross-sectional study, 117 patients participated in the study. All pregnant women had positive RT-PCR results for SARS-CoV-2 RNA. Nasopharyngeal and oropharyngeal swabs were used to detect Covid-19 infection. To perform amniotic fluid sampling, a sterile needle was inserted through the vagina and 10 cc of amniotic fluid was carefully inserted under sterile conditions just before rupture of the membranes and before leakage. Data were statistically analyzed using SPSS software version 24.
Results: There was no difference between the sexes of newborns among the 10 positive amniotic fluid tests compared to the negative cases of this test (P> 0.05). The mean weight of neonates with positive amniotic fluid was 2927 gr. In neonates with negative COVID PCR test in the amniotic fluid; this figure was 3104 gr, which was not statistically significant despite the difference of 117 gr (P> 0.05). Also, there was no statistically significant difference between the two groups, including positive and negative cases of Covid-19 in amniotic fluid test and in parameters including height, weight, heart rate, respiratory rate and minute Apgar score of one and five newborns (P> 0.05).
Conclusion: Because the amniotic fluid is sterile and the placental barrier prevents most microorganisms from passing through, it seems that the Covid-19 virus can cross this barrier in some cases and contaminate the amniotic fluid. However, this infection does not have a significant effect on embryonic parameters.
Article number: 7
Article Type: Original Research |
Subject:
Women Diseases
Received: 2022/09/24 | Accepted: 2022/09/24 | Published: 2022/09/24
Received: 2022/09/24 | Accepted: 2022/09/24 | Published: 2022/09/24
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