Volume 3, Issue 2 (2018)
SJMR 2018, 3(2): 121-126 |
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Roumandeh N, Zare A, Saremi A. Immunology of Recurrent Spontaneous Abortion. SJMR 2018; 3 (2) :121-126
URL: http://saremjrm.com/article-1-66-en.html
URL: http://saremjrm.com/article-1-66-en.html
1- Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran , ahadzr@gmail.com
3- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran , ahadzr@gmail.com
3- “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
Abstract: (13416 Views)
Introduction: Recurrent Spontaneous Abortion (RSA) is one of the most common complications in reproductive ages. Several factors such as genetic, anatomical, and endocrine disorders, infection, and environmental and immunological factors have been involved in RSA. In cases of abortions, whose reasons are known, the chance of success in pregnancy can be increased after the elimination of the defective factors; but, in women with a history RSA with an unknown reason, there is an imbalance in the regulatory mechanisms of immune cells, and even the pattern of immunological cells changes in these women. Actually, an inappropriate immune response is often associated with pregnancy loss. Immunologic factors involved in patients with RSA have gradually been identified, using diagnostic methods and several studies. The present study was conducted with the aim of reviewing RSA immunology and new findings in this field. In this study, more than 40 articles on immunologic factors involved in RSA were reviewed.
Conclusion: Based on the current findings related to the immunology of pregnancy, due to the extensive role of the immunologic factors in this disorder, more accurate identification of the functional role of each immunologic factor becomes more important. Also, new therapeutic approaches will be addressed to the researchers in this field based on the changes in the function of immune system.
Article Type: Systematical Review |
Subject:
Reproduction
Received: 2017/03/15 | Accepted: 2017/06/26 | Published: 2018/08/23
Received: 2017/03/15 | Accepted: 2017/06/26 | Published: 2018/08/23
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