Volume 8, Issue 4 (2023)
SJMR 2023, 8(4): 249-254 |
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Pakzad H, Hayatgheybi S R, Chegini A, Tajar S, Kashefi Baher M, Abbasi B. Prevalence and Distribution of Human Papillomavirus Genotypes Among Patients in National Institute of Genetic Engineering and Biotechnology Laboratory (NIGEB Lab) in 2024. SJMR 2023; 8 (4) : 4
URL: http://saremjrm.com/article-1-321-en.html
URL: http://saremjrm.com/article-1-321-en.html
Hossein Pakzad1 
, Seyed Reza Hayatgheybi1 , Ahmad Chegini1 , Salar Tajar1 , Mohammadreza Kashefi Baher2 , Bahareh Abbasi *1
, Seyed Reza Hayatgheybi1 , Ahmad Chegini1 , Salar Tajar1 , Mohammadreza Kashefi Baher2 , Bahareh Abbasi *1
1- Department of Medical Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
2- Academic Dentist, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Academic Dentist, Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract: (899 Views)
Human Papillomavirus (HPV) is a leading cause of cervical cancer, with various genotypes exhibiting differing levels of carcinogenic risk. This study investigates the prevalence and distribution of HPV genotypes among patients who tested positive during routine gynecological visits at Nigeb Laboratory. Conducted from January to June 2022, this cross-sectional study involved 152 women aged 18 and older. Cervical samples were collected and analyzed for HPV DNA using Real-Time Polymerase Chain Reaction (RT-PCR) analysis to determine genotype distribution. Among the participants, 68.4% were positive for carcinogenic HPV genotypes, with HPV 16 being the most prevalent (13.8%), followed by HPV 56 (12.5%) and HPV 66 (12.5%). Benign HPV genotypes were found in 19.1% of the samples, with HPV 6 (16.4%) being the most common. These findings underscore the need for comprehensive HPV vaccination and regular screening programs. The high prevalence of high-risk HPV genotypes not covered by current vaccines suggests the necessity for broader vaccine formulations. This study provides valuable data for informing public health strategies and highlights the importance of continuous HPV surveillance and research in under-researched populations.
Article number: 4
Article Type: Original Research |
Subject:
Women Diseases
Received: 2023/12/26 | Accepted: 2024/01/31 | Published: 2024/11/12
Received: 2023/12/26 | Accepted: 2024/01/31 | Published: 2024/11/12
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