Introduction: Cytomegalovirus (CMV) is a member of the β-Herpes family, which produces cytomegalic inclusions in infected cells. This virus produces a syndrome similar to infectious mononucleosis. Presence of specific antibodies against Cytomegalovirus in persons ‘ serum shows that, people contact with CMV during their lifetime. The first encounter with this virus during pregnancy can cause abnormalities such as cardiomegaly, hydrocephalus, and even fetal death.
Patient Information: This case report concerns a 27 weeks fetus from a 27 year old mother at Sarem Hospital. According to the pathologic findings of the samples stained with H&E and PAS methods, molecular tests were performed to detect Cytomegalovirus, and after DNA extraction from paraffin blocks obtained from different tissues of the fetus using Nested-PCR with two pairs of primers (CMTR1, CMTR2, CMTR3, and CMTR4), the presence of this virus was investigated in two stages.
Conclusion: Regarding the healthy karyotype and the absence of genetic problems and molecular investigations, the main cause of the changes in the fetus, including cardiomegaly, hydrocephalus, and the cause of fetal death in the 27th week, is the presence of Cytomegalovirus.