@ARTICLE{Giti, author = {Giti, Sima and }, title = {Successful pregnancy following treatment of placental Chronic Intervillous Histiocytosis: a case report study}, volume = {6}, number = {4}, abstract ={Introduction: Chronic Histiocytic Intervillositis (CHI) is a placental lesion that is associated with high fetal morbidity and mortality, and definitive criteria for the diagnosis of this factor have not been established. With considering the importance of complications and high fetal mortality, the aim of this study was a successful pregnancy following the treatment of placental Chronic Histiocytosis Intervillositis in the form of a case report. Case introduction: A 37-year-old woman (G3P1Ab1L1) with a body mass index (BMI) of 26.7 referred to the perinatal clinic at Sarem Hospital in Tehran. She had normal menstrual cycles with duration of 3 to 7 days and an interval of 28 days. The patient did not have amenorrhea, dysmenorrhea, or spotting, and her bleeding was normal. Also, the patient had thrombophilia and was hospitalized at 34 weeks due to placental histiocytosis, polyhydramnios, and Doppler condition. The left ovary had a small adhesion to the tubes and it was opened. A 15 cm cyst was observed and the fluid was referred to cytology, which fortunately was not malignant and the left ovary was restored. Conclusion: There are still many unknowns about CHI and the current evidence is limited by a single case report. Although, the evidence for rare diseases is weaker, there are ways to overcome these problems. Furthermore, prospective studies on unselected samples, determining the full range of prognosis associated with CHI, as well as identifying a clear relationship between the disease and pregnancy outcomes, would reduce the possibility of selection or reporting bias. }, URL = {http://saremjrm.com/article-1-236-en.html}, eprint = {http://saremjrm.com/article-1-236-en.pdf}, journal = {Sarem Journal of Medical Research}, doi = {10.52547/sjrm.6.4.2}, year = {2021} }