Volume 3, Issue 1 (2018)                   SJMR 2018, 3(1): 59-64 | Back to browse issues page

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Sarafzadeh A, Jamalou M, Roustaei Z. Placental Pathologies in the Preterm Labors. SJMR. 2018; 3 (1) :59-64
URL: http://saremjrm.com/article-1-97-en.html
1- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran , alirezasarrafzadeh@yahoo.com
2- Information Technology (IT) Department, Management Faculty, University of Tehran, Tehran, Iran
3- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Abstract:   (9759 Views)

Aims: The placenta provides oxygen and nutrients to fetus and plays a central role in embryonic development. Abnormal growth of the placenta is associated with negative pregnancy outcomes. Preterm labor is one of the most important outcomes of placental abnormalities. The objective of this study was to investigate the pathology of placenta in preterm labor and prediction of neonate’s outcomes.
Materials & Methods: This cross-sectional study was conducted on 118 placentas obtained from preterm labor cases in Sarem women’s hospital (Tehran, Iran) during one year. At least 3 specimens were taken from each placenta and stained with H& E and examined by pathologists, microscopically. The data were analyzed by logistic regression analysis.
Findings: No pathological changes were found in 89.5% of the placentas; however, 10.0% of the placentas showed pathological changes. Three parameters, including syncytial knots, chorangiosis and microcalcification were the most effective variables on pathological results. Accordingly, increase of one unit in syncytial knot raise the chance of preterm labor 0.01 fold. Besides, the change in the amount of chorangiosis can increase the chance of preterm labor 0.252 fold and changes in Microcalcification can raise the chance for preterm labor up to 0.14 fold on average.
Conclusion: Syncytial knots, chorangiosis and microcalcification are the most effective pathological changes in the pathology of placenta in preterm labor.

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Article Type: Original Research | Subject: Reproduction
Received: 2017/01/14 | Accepted: 2017/05/15 | Published: 2018/05/22

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