Volume 7, Issue 1 (2022)
SJMR 2022, 7(1): 1-14 |
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Hassani Bafrani M, Amini Mahabadi A, Hassani bafrani H, Barandeh B. The Application of Mesenchymal Stem Cells Derived From Different Sources in the Treatment of Infertility: A Review Article. SJMR 2022; 7 (1) :1-14
URL: http://saremjrm.com/article-1-251-en.html
URL: http://saremjrm.com/article-1-251-en.html
1- Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2- Responsible for administrative affairs, Payame Noor University, Ardestan, Isfahan, Iran
3- Full Professor of Anatomicalscience, Gametogenesis Research Center,Kashan University of Medical Sciences,Kashan, Iran , hhassanib@gmail.com
4- Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran
2- Responsible for administrative affairs, Payame Noor University, Ardestan, Isfahan, Iran
3- Full Professor of Anatomicalscience, Gametogenesis Research Center,Kashan University of Medical Sciences,Kashan, Iran , hhassanib@gmail.com
4- Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran
Abstract: (861 Views)
Introduction: Infertility is a common and complex disease that affects 10-15% of couples of reproductive age worldwide. Today, although the Assisted Reproduction Teqniques (ARTs) are considered as the most effective method for infertility treatment in humans, the use of these methods are limited. Due to their biological characteristics, stem cells can regulate immunological mechanisms and repair and regenerate the uterus, ovaries and fallopian tube tissues. Recently, treatment with mesenchymal stem cells (MSCs) has been considered as a new option for the treatment of infertility. Therefore, the purpose of this study is to investigate the use of mesenchymal stem cells extracted from different tissues for the treatment of male and female infertility.
Conclusion: MSCs are strong candidates for cell therapy with growth factor-enhancing activity and superior immunomodulatory capacity. The side effects of the treatment of these cells can be controlled to some extent, and there may be a relationship between the treatment and the occurrence of cancer, as well as mortality in treated patients. However, longer follow-ups are needed to study late events, especially in tumor formation and progression.
Conclusion: MSCs are strong candidates for cell therapy with growth factor-enhancing activity and superior immunomodulatory capacity. The side effects of the treatment of these cells can be controlled to some extent, and there may be a relationship between the treatment and the occurrence of cancer, as well as mortality in treated patients. However, longer follow-ups are needed to study late events, especially in tumor formation and progression.
Article number: 1
Article Type: Analytical Review |
Subject:
Sterility
Received: 2022/04/21 | Accepted: 2022/05/15 | Published: 2023/01/8
Received: 2022/04/21 | Accepted: 2022/05/15 | Published: 2023/01/8
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