Volume 6, Issue 3 (2021)                   SJMR 2021, 6(3): 163-168 | Back to browse issues page

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Roumande N, Amini Mahabadi J, Saremi A, Nateghi M R, Sanaye Naderi M, Zare A. Evaluation of complement system function and C3 and C4 levels in patients with recurrent spontaneous abortion. SJMR. 2021; 6 (3) :163-168
URL: http://saremjrm.com/article-1-232-en.html
1- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran.
2- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran.
3- Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women's Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran. & Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran. & Department of Immunology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. , ahadzareee@gmail.com
Abstract:   (175 Views)
Introduction: Recurrent miscarriage is the most common pregnancy problem and is often defined as two or more recurrent miscarriages before the twentieth week of pregnancy. The complement system with the mechanism of lysis of bacteria and extracellular pathogens focuses on the elimination of these foreign agents and can be effective in regulating normal pregnancy and preserving or rejecting the semi-allogeneic fetus. The aim of this study was the evaluation of the function of the complement system and the levels of C3 and C4 in patients with recurrent miscarriage.
Material & Methods: In this case-control study, two groups were referred to Sarem women's Hospital in Tehran during the period of 2020 to 2021. The referred patients were 77 females with a history of at least three recurrent spontaneous abortions as the case group and 37 healthy women without a history of abortion with at least one live child as the control group. Patients were evaluated for karyotype, anti-phospholipid antibody, anti-cardiolipin, ANA, anti-thyroid antibody, recurrent abortion-related infections, anatomical abnormalities, and hormonal disorders. To measure the activity of the complement system, CH50 test was performed using SRID method and the levels of C3 and C4 were detected by nephelometry method. The measured values ​​were analyzed by SPSS software version 22.
Results: The present study showed that the levels of complement proteins, C3 and C4, were significantly reduced in women with recurrent miscarriage compared to the control group. Also, the comparison of complement activity in these two groups showed less serum complement activity in patients with a history of recurrent miscarriage.
Conclusion:  Considering the possible involvement of complement proteins in recurrent spontaneous abortion, examining the level of major complement proteins such as C3 and C4 and measurement of the serum complement activity of these patients can be useful in diagnosing abortions due to immunological causes.
 
Article number: 5
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Article Type: Original Research | Subject: Sterility
Received: 2021/09/1 | Accepted: 2021/09/15 | Published: 2022/08/9

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