Volume 5, Issue 4 (2020)                   SJMR 2020, 5(4): 180-186 | Back to browse issues page

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Kamani M, Nikzad H. Effect of Allium Cepa Seed Extracts on the Histopathological Changes of Ventral Prostatic Lobe in Diabetic Rats. SJMR. 2020; 5 (4) :180-186
URL: http://saremjrm.com/article-1-202-en.html
1- Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2- Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran. , nikzad_h@kaums.ac.ir
Abstract:   (76 Views)
Introduction: Diabetes can have adverse effects on spermatogenesis. The onion plant (Allium Cepa) contains many antioxidants. The aim of this study was to evaluate the anti-diabetic functions of onion seed hydroalcoholic extract on histopathological changes of prostate ventral lobe in streptozotocin-induced diabetic rats with streptozotocin.
Methods: In this experimental study, diabetes was induced in the animals using streptozotocin (STZ; 60 mg/kg). Fifty rats were equally divided into five groups as follows: Groups 1, nondiabetic (normal) controls received only 0.1 ml normal saline via gastric gavage; group 2, diabetic controls induced by streptozotocin; groups 3 and 4 were diabetic rats that received 200 and 400 mg/kg B.W of Allium Cepa seed extract by gavage for 4 weeks and Group 5, diabetic animals that received streptozotocin plus insulin in dose 3U/100g B.W. At the end of this study, rats were anesthetized, and the ventral prostatic lobe was removed and processed for histological studies. Then, blood sugar and histopathology changes were analyzed and compared.
Findings: The administration of 200 and 400 mg/kg doses of onion seed extract could recover duct epithelium height of the ventral prostatic lobe in streptozotocin-diabetic rats from 2.37 ± 1.00 to 6.10 ± 1.19 µm. Also, consumption of this extract with a dose of 200 mg/kg had hypoglycemia effects in diabetic rats
.Conclusion: The consumption of the onion seed extract can reduce harmful effects of the streptozotocin histopathology in the ventral prostatic lobe of diabetic rats.
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Article Type: Original Research | Subject: Reproduction
Received: 2021/09/5 | Accepted: 2021/09/5 | Published: 2021/09/5

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