AU - Abdi, A. AU - Bagherizadeh, I. AU - Vand-Rajabpour, V. AU - Shafaghati, Y. AU - Behjati, F. TI - Rare Cytogenetic Findings of Two Iranian Female Patients with Premature Ovarian Failure PT - JOURNAL ARTICLE TA - saremjm JN - saremjm VO - 4 VI - 2 IP - 2 4099 - http://saremjrm.com/article-1-138-en.html 4100 - http://saremjrm.com/article-1-138-en.pdf SO - saremjm 2 ABĀ  - Introduction: Premature ovarian failure (POF) is defined by ovarian failure, amenorrhea, sex steroid deficiency, and elevated (menopausal) levels of serum gonadotropins before the age of 40 years. Chromosome abnormalities are the cause of 5-10% of POF cases. The aim of this study was to report chromosomal abnormalities, with X chromosome involvement, in two patients with POF, referred to Sarem Hospital in Tehran. Patients’ Information: Two patients with a POF diagnosis were referred to the cytogenetic laboratory of Sarem Hospital in 2014-20115. The chromosomal analysis of a 16-year-old girl and a 26-year-old woman (both with POF) by high resolution GTG banding technique showed structural chromosome abnormities and 46,X,der(X) and 45,dic(X;22)(q22;p12) Karyotypes were observed, respectively. Conclusion: Cytogenetic investigation in patients with POF is of great value and highly recommended. CP - IRAN IN - Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran LG - eng PB - saremjm PG - 123 PT - Case Report YR - 2019